News tagged with chaperone protein
The dance of the chaperones: Scientists identify key player of protein folding
Proteins are the molecular building blocks and machinery of cells and involved in practically all biological processes. To fulfil their tasks, they need to be folded into a complicated three-dimensional structure. Scientists ...
Mar 08, 2012 |
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It takes two to tango: Pairs of entwined proteins handle the stress
(PhysOrg.com) -- Imagine two tango dancers sweeping across the dance floor and suddenly encountering a slick spot. To avoid a slip or even a nasty tumble, the pair must work together to support one another ...
Mar 02, 2012 |
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Researchers provide atomic view of a histone chaperone
Mayo Clinic researchers have gained insights into the function of a member of a family of specialized proteins called histone chaperones. Using nuclear magnetic resonance (NMR) spectroscopy and X-ray crystallography, they ...
Mar 01, 2012 |
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Energy-saving chaperon Hsp90
A special group of proteins, the so-called chaperons, helps other proteins to obtain their correct conformation. Until now scientists supposed that hydrolyzing ATP provides the energy for the large conformational ...
Jan 13, 2012 |
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A chaperone for the 'guardian of the genome'
The protein p53 plays an essential role in the prevention of cancer by initiating the controlled death of a cell with damaged genes which is in danger to transform into a cancerous cell. The heat shock protein Hsp90, in turn, ...
Sep 07, 2011 |
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Chaperone enzyme provides new target for cancer treatments
UNC scientists who study how cells repair damage from environmental factors like sunlight and cigarette smoke have discovered how a "chaperone" enzyme plays a key role in cells' ability to tolerate the DNA damage that leads ...
Jan 18, 2011 |
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Dynamics of chaperone protein critical in rescuing brains of Alzheimer's mice from neuron damage
Dynamic regulation of the chaperone protein Hsp27 was required to get rid of abnormally accumulating tau in the brains of mice genetically modified to develop the memory-choking tau tangles associated with ...
Medicine & Health / Neuroscience
Dec 03, 2010 |
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Scientists find ideal target for malaria therapy
Scientists at Washington University School of Medicine in St. Louis have identified a protein made by the malaria parasite that is essential to its ability to take over human red blood cells.
Medicine & Health / Medical research
Feb 03, 2010 |
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Chaperonins prompt proper protein folding -- but how?
In proper society of yesterday, the chaperone insured that couples maintained proper courting rituals. In biology, a group of proteins called chaperonins makes sure that proteins are folded properly to carry out their assigned ...
Jan 20, 2010 |
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Researchers find new method of fixing broken proteins to treat genetic diseases
Researchers at Fox Chase Cancer Center have demonstrated how it could be possible to treat genetic diseases by enhancing the natural ability of cells to restore their own mutant proteins. In particular, they found that drugs ...
Jan 15, 2010 |
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Chaperones for climate protection
(PhysOrg.com) -- The World Climate Conference recently took place. Reports about carbon dioxide levels, rising temperatures and melting glaciers appear daily. Scientists from the Max Planck Institute (MPI) ...
Jan 14, 2010 |
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Molecular chaperone keeps bacterial proteins from slow-dancing to destruction
Just like teenagers at a prom, proteins are tended by chaperones whose job it is to prevent unwanted interactions among immature clients. And at the molecular level, just as at the high school gym level, it's a job that usually ...
Dec 28, 2009 |
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Research sheds light on workings of anti-cancer drug
(PhysOrg.com) -- The copper sequestering drug tetrathiomolybdate (TM) has been shown in studies to be effective in the treatment of Wilson disease, a disease caused by an overload of copper, and certain metastatic cancers. ...
Chemistry / Analytical Chemistry
Nov 26, 2009 |
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New way to fight drug-resistant fungal infections discovered
(PhysOrg.com) -- The secret to fighting often lethal drug resistant fungal infections is to knock out the bug's molecular chaperone, according to U of T researchers.
Jul 31, 2009 |
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Targeting helpers of heat shock proteins could help treat cancer, cardiovascular disease
Dissecting how heat shock protein 90 gets steroid receptors into shape to use hormones like estrogen and testosterone could lead to targeted therapies for hormone-driven cancers, such as breast and prostate, ...
Jun 22, 2009 |
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