Exotic signaling mechanism in pathogens

The unicellular parasite that causes sleeping sickness differs from other eukaryotes in the mode of regulation of an essential cellular signaling pathway. This provides a promising point of attack for drug development.

Discovery of a potential therapeutic target to combat trypanosomes

Yaser Hashem's team at the Laboratoire Architecture et Réactivité de l'ARN at CNRS's has discovered a new potential therapeutic target - located in the ribosome - to combat trypanosomes parasites. Using cryo-electron microscopy, ...

Scientists identify new hosts for Chagas disease vectors

Solitary weasel-like animals called tayra might look pretty harmless, but some may actually be incubators for a parasite that causes Chagas disease, a chronic, debilitating condition that is spread by insects called kissing ...

New enzyme-mapping advance could help drug development

Scientists at MIT and the University of São Paulo in Brazil have identified the structure of an enzyme that could be a good target for drugs combatting three diseases common in the developing world.

Stealth nanocapsules kill Chagas parasites in mouse models

Lychnopholide, a substance isolated from a Brazilian plant, and formulated as part of "nanocapsules" cured more than half of a group of mice that had been infected experimentally with Chagas disease parasites. "Chagas disease ...

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