New production process for therapeutic nanovesicles

Particles known as extracellular vesicles play a vital role in communication between cells and in many cell functions. Released by cells into their environment, these "membrane particles" consist of a cellular membrane carrying ...

Discovery of a cellular uptake pathway for larger drug molecules

Recent findings by UCSF and Arc Institute scientists open up new possibilities for overcoming a fundamental challenge in drug discovery. There can be a tradeoff between optimizing a drug's key-in-a-lock fit with its target ...

A revolutionary method to observe cell transport

Membrane proteins are key targets for many drugs. They are located between the outside and inside of our cells. Some of them, called transporters, move certain substances in and out of the cellular environment. Yet, extracting ...

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