Research reveals how cancer-driving enzyme works

Cancer researchers at UT Southwestern Medical Center are helping unlock the cellular-level function of the telomerase enzyme, which is linked to the disease's growth.

Another piece of the ion pump puzzle

From bacteria to humans, all cells use molecules of adenosine triphosphate (ATP) as fuel to power a broad range of biochemical reactions. For example, massive multi-subunit enzymes known as V-ATPases convert ATP molecules ...

Researchers identify key player in cellular response to stress

An enzyme called Fic, whose biochemical role was discovered at UT Southwestern more than a dozen years ago, appears to play a crucial part in guiding the cellular response to stress, a new study suggests. The findings, published ...

New role for the JNK protein

Put simply, a tumor is the result of out-of-control cell growth. To assure that the cell cycle - the cell's process of duplicating itself to make more cells - goes smoothly, a large network of proteins tells other proteins ...

A question of gene silencing

When investigating cancer cells, researchers discovered numerous peculiarities: Particular RNA molecules are present in large numbers, particular genes are overactive. Do these characteristics have a relation to cancer? Do ...

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