The filaments that structure DNA

They play a leading role not only in muscle cells: Actin filaments are one of the most abundant proteins in all mammalian cells. The filigree structures form an important part of the cytoskeleton and locomotor system. Cell ...

Neural network fills in data gaps for spatial analysis of chromosomes

Computational methods used to fill in missing pixels in low-quality images or video also can help scientists provide missing information for how DNA is organized in the cell, computational biologists at Carnegie Mellon University ...

How cells protect themselves from mitochondrial defects

Cells need powerhouses known as mitochondria to utilize the energy stored in our food. Most of the proteins required for this powerhouse function are encoded in the nucleus and transported into the mitochondria after they ...

How chromosomes change their shape during cell differentiation

The human genome is made up of 46 chromosomes, each of which has a length of about 100 to 200 million base pairs, the building blocks of the DNA double helix. Even during interphase, the period in between the cell division ...

Mathematical modeling shows why animals see at night

Nocturnal and diurnal mammals see the same—but only for a brief time. When mice are born, the chromatin in the cells of their eyes has a diurnal structure. Day by day, the layout of this chromatin slowly inverts, allowing ...

Upcycling of proteins protects DNA from parasites

Of the three billion base pairs in the human genome, less than two percent contain the information encoding the ~20,000 proteins. That is, because at least half of our genetic material originated from selfish genetic elements ...

Gatekeepers of the genome

Transcription factors control gene activation in cells. By binding to specific segments of DNA, they enable the blueprints that code for cellular proteins to be produced. But how are such factors themselves regulated?

New insight into microRNA function can give gene therapy a boost

Scientists at the University of Eastern Finland and the University of Oxford have shown that small RNA molecules occurring naturally in cells, i.e. microRNAs, are also abundant in cell nuclei. Previously, microRNAs were mainly ...

New function for the nucleolus

The nucleolus is a well-known structure in the cell nucleus that is easily visible under a light microscope. This nuclear structure is known to be the site of ribosome production. A new study shows that the nucleolus is also ...

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