Pancreatic cancer cell invasion along nerves is regulated by a paracrine pathway that involves glial cell-derived neurotrophic factor, which may be a possible target for preventing the invasion, according to a new study published ...
Jan 13, 2010
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The research group of Professor Magdalena Gotz of Helmholtz Zentrum Munchen and Ludwig-Maximilians-Universitat Munich (Germany) has made a significant advance in understanding regeneration processes in the brain. The researchers ...
Dec 01, 2009
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Two signaling pathways essential to normal human development - the Wnt/Wingless (Wnt) and epidermal growth factor receptor (EGFR) pathways - interact in ways that can promote tumor cell invasion and metastasis, researchers ...
Nov 25, 2009
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Researchers at the Burnham Institute for Medical Research have discovered that reactive oxygen species, such as superoxide and hydrogen peroxide, play a key role in forming invadopodia, cellular protrusions implicated in ...
Sep 16, 2009
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A new study identifies a molecule that acts cooperatively with a well known oncoprotein to drive progression of noninvasive breast cancer to metastatic, life-threatening disease. The research findings, published by Cell Press ...
Sep 08, 2009
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Researchers funded by the National Institutes of Health have found that the activity of a protein in brain cells helps stimulate the spread of an aggressive brain cancer called glioblastoma multiforme (GBM). In a move toward ...
Aug 18, 2009
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(PhysOrg.com) -- The development of the brain proceeds a little like the European settlement of North America. The earliest pioneers settled on the east coast with subsequent waves of settlers forming communities further ...
Jul 23, 2009
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The molecular machinery that helps brain cells migrate to their correct place in the developing brain has been identified by scientists at St. Jude Children's Research Hospital. The finding offers new insight into the forces ...
Jul 15, 2009
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Scientists at Burnham Institute for Medical Research (Burnham) have discovered that specialized complex sugar molecules (glycans) that anchor cells into place act as tumor suppressors in breast and prostate cancers. These ...
Jul 06, 2009
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Research led by David Worthylake, PhD, Assistant Professor of Biochemistry and Molecular Biology at LSU Health Sciences Center New Orleans, may help lay the groundwork for the development of a compound to prevent the spread ...
May 21, 2009
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Researchers at the Department of Energy's Oak Ridge National Laboratory and St. Jude Children's Research Hospital are looking at how developing nerve cells may hold a key to predicting and preventing diseases like cancer ...
Mar 30, 2009
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Migration of colonic lamina propria fibroblasts (CLPF) plays an important role during the progression of fibrosis and fistulae in Crohn's disease. Transforming growth factor- beta (TGF- beta) is involved in the regulation ...
Mar 30, 2009
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Researchers from Thomas Jefferson University have identified a protein that appears to play a significant role in the growth and migration of prostate cancer cells, especially androgen-independent prostate cancer cells. The ...
Feb 26, 2009
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Tumors that are about to progress and metastasize go through a process also seen in normal embryonic development, known as the epithelial to mesenchymal transition (EMT). Tumor cells revert to a less-differentiated state, ...
Feb 23, 2009
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A team of Vanderbilt University Medical Center investigators has developed a group of chemical compounds that could represent a new class of drugs for treating cancer.
Feb 03, 2009
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