Some 50 years have passed since scientists first proposed the so-called 'inside–outside model' of development, which holds that the inner cells of the early embryo eventually form all the definitive structures ...
Apr 10, 2013
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The field of regenerative medicine holds great promise, propelled by greater understanding of how stem cells differentiate themselves into many of the body's different cell types. But clinical applications ...
Mar 28, 2013
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Researchers at the A*STAR Institute of Medical Biology (IMB) have discovered a critical checkpoint protein that controls when human embryonic stem cells (hESCs) begin to differentiate.
Feb 27, 2013
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Every gene in the nucleus of an animal or plant cell is packaged into a beads-on-a-string like structure called nucleosomes: the DNA of the gene forms the string and a complex of proteins called histones forms the beads around ...
Feb 11, 2013
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Chromatin remodeling—the packaging and unpackaging of genomic DNA and its associated proteins—regulates a host of fundamental cellular processes including gene transcription, DNA repair, programmed cell ...
Nov 29, 2012
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Notch – the protein that can help determine cell fate – maintains a stable population of basal cells in the prostate through a positive feedback loop system with another key protein – TGF beta (transforming growth factor ...
Nov 01, 2012
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What happens to a stem cell at the molecular level that causes it to become one type of cell rather than another? At what point is it committed to that cell fate, and how does it become committed? The answers ...
Apr 12, 2012
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(PhysOrg.com) -- An international team of biochemists, biophysicists, and neutron scientists are using a combination of fluorescence and small-angle neutron scattering (SANS) techniques to assist biochemists ...
Dec 15, 2011
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(PhysOrg.com) -- Scientists from the Friedrich Miescher Institute for Biomedical Research (FMI) publish exciting new results on the regulation of cell fate in the scientific journal Nature. They identified ...
Dec 15, 2011
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Discovering the step-by-step details of the path embryonic cells take to develop into their final tissue type is the clinical goal of many stem cell biologists. To that end, Kenneth S. Zaret, PhD, professor ...
May 19, 2011
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Members of a population of identical cells often "choose" different fates, even though they exist in identical conditions.
May 13, 2010
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