Researchers from Karolinska Institutet have discovered a new molecular mechanism by which cancer cells safeguard themselves from oncogene-induced replication stress and propose a strategy to deactivate this protective mechanism. ...
Cell & Microbiology
Aug 17, 2023
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45
Chemotherapy and radiotherapy aim to destroy cancer cells by inducing DNA double-strand breaks—damage that, once inflicted, usually causes the cells to die. But damage to a cell's genetic material also activates a signaling ...
Biochemistry
Jul 27, 2023
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61
A protein that packs massive DNA strands into tiny cells also moonlights as a cleaner of damaged genetic material. This discovery could help detect mitochondrial diseases, which can cause brain damage and organ failure.
Cell & Microbiology
Jul 26, 2023
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1
Researchers at the Indian Institute of Science (IISc) have designed a short peptide capable of poisoning a key enzyme in disease-causing bacteria, including some of most deadly and antibiotic-resistant species.
Cell & Microbiology
Jul 20, 2023
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12
During embryonic development, the programmed death of certain cells plays an essential role in shaping organs and allowing proper growth. This cell death is in some cases an effect of autophagy, a key cellular process responsible ...
Cell & Microbiology
Jul 19, 2023
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1
The tumor suppressor protein p53 has been dubbed the "guardian of the genome" because it protects the DNA from stress or long-term damage by regulating the expression of numerous genes involved DNA repair, cell division and ...
Molecular & Computational biology
Jun 30, 2023
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50
Protein aggregates accumulate during aging and are linked to neurodegenerative diseases like Alzheimer's, Parkinson's or Huntington's disease. A new study by the Nyström lab at Gothenburg University, in collaboration with ...
Cell & Microbiology
Jun 29, 2023
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1
Cells in the human body, the building blocks of life, are arranged in a precise way. That's necessary because pathways and spaces provide a means for cells to communicate, collaborate and function within the specific tissue ...
Cell & Microbiology
Jun 26, 2023
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6
Scientists studying gene activity data of the early human embryo have discovered an overlooked type of cell that self-destructs within days of forming, as part of a quality control process to protect the developing fetus. ...
Cell & Microbiology
Jun 20, 2023
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304
Our genomic DNA is continuously damaged by endogenous factors such as reactive oxygen species, and also by environmental factors such as ultraviolet light, radiation, and chemicals. Failure to repair damaged DNA may induce ...
Molecular & Computational biology
Jun 12, 2023
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