News tagged with brca1
Revolutionary therapy slows tumor growth in advanced breast cancer
The new drug olaparib has antitumour activity in carriers of the BRCA1 or BRCA2 gene mutations who have advanced ovarian or breast cancer, according to the findings of two proof-of-concept trials. Together with previous findings, ...
Jul 05, 2010 |
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Genetic 'hotspot' for breast cancer risk
Vanderbilt-Ingram Cancer Center investigators have identified a new genetic hotspot for breast cancer.
Feb 15, 2009 |
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Stem cell 'daughters' lead to breast cancer
Walter and Eliza Hall Institute scientists have found that a population of breast cells called luminal progenitor cells are likely to be responsible for breast cancers that develop in women carrying mutations ...
Aug 02, 2009 |
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Only women with Western Swedish breast cancer gene run higher risk of ovarian cancer
Previous research has shown that women with breast cancer are more likely than other women to develop ovarian cancer, but now researchers from the Sahlgrenska Academy at the University of Gothenburg, Sweden, have shown that ...
Apr 05, 2010 |
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BRCA1
BRCA1 ( /ˈbrækə/; breast cancer 1, early onset) is a human caretaker gene that produces a protein called breast cancer type 1 susceptibility protein, responsible for repairing DNA. The first evidence for the existence of the gene was provided by the King laboratory at UC Berkeley in 1990. The gene was later cloned in 1994 by scientists at Myriad Genetics.
BRCA1 is expressed in the cells of breast and other tissue, where it helps repair damaged DNA, or destroy cells if DNA cannot be repaired. If BRCA1 itself is damaged, damaged DNA is not repaired properly and this increases risks for cancers.
The protein encoded by the BRCA1 gene combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). The BRCA1 protein associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. Thus, this protein plays a role in transcription, DNA repair of double-stranded breaks ubiquitination, transcriptional regulation as well as other functions.
For more information about BRCA1, read the full article at
Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
