News tagged with brca1
Genetic 'hotspot' for breast cancer risk
Vanderbilt-Ingram Cancer Center investigators have identified a new genetic hotspot for breast cancer.
Feb 15, 2009 |
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Revolutionary therapy slows tumor growth in advanced breast cancer
The new drug olaparib has antitumour activity in carriers of the BRCA1 or BRCA2 gene mutations who have advanced ovarian or breast cancer, according to the findings of two proof-of-concept trials. Together with previous findings, ...
Jul 05, 2010 |
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Dartmouth researchers get personal with genetics
Two recent studies by Dartmouth researchers use individual genetic data to reveal the powers and limits of our current understanding of how the genome influences human health and what genes can reveal about the ancestry of ...
Sep 15, 2009 |
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Stem cell 'daughters' lead to breast cancer
Walter and Eliza Hall Institute scientists have found that a population of breast cells called luminal progenitor cells are likely to be responsible for breast cancers that develop in women carrying mutations ...
Aug 02, 2009 |
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Research suggests link between infertility, low egg reserve, and breast/ovarian cancer gene (BRCA1)
A New York Medical College physician who specializes in restoring or preserving fertility in female cancer patients has discovered a possible link between the presence of breast cancer genes and infertility.
Dec 18, 2009 |
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Loss of protein could contribute to early breast and ovarian cancer deaths
(PhysOrg.com) -- The loss of a cell repair protein in a large proportion of women battling breast or ovarian cancer could explain why they die early, new research suggests.
Feb 01, 2011 |
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'Basal-like' breast cancer does not originate from basal stem cells
New research uncovers a case of mistaken identity that may have a significant impact on future breast cancer prevention and treatment strategies. The study, published by Cell Press in the September 3rd issue of the journal ...
Sep 02, 2010 |
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Researchers identify a new breast and ovarian cancer susceptibility gene
A group of researchers report evidence unambiguously implicating the gene RAD51C in susceptibility to breast and ovarian cancer. This gene normally plays a role in DNA repair. By screening RAD51C in unrelated individuals ...
Apr 21, 2010 |
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Pathways that Can Repair Brca1 Cancer Gene Mutation Clarified in Mice
(PhysOrg.com) -- In a new study in mice, scientists have compensated for mutations in the Brca1 gene that can lead to cancer by deleting a second gene, which then lessens the probability of cancer. Mice Brca1-associated mammary ...
Apr 01, 2010 |
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Coping with genetic predisposition to cancer
Kelly Metcalfe, a professor at the Bloomberg Faculty of Nursing, focuses her research on a unique population of women faced with some really tough decisions and helps them reach satisfactory conclusions.
Sep 29, 2010 |
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Only women with Western Swedish breast cancer gene run higher risk of ovarian cancer
Previous research has shown that women with breast cancer are more likely than other women to develop ovarian cancer, but now researchers from the Sahlgrenska Academy at the University of Gothenburg, Sweden, have shown that ...
Apr 05, 2010 |
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Breast cancer: Risk increases for smokers and overweight women
A recent study published in the Journal of Cancer Epidemiology has reinforced the correlation between being overweight, smoking and breast cancer. What makes this study unique is how test subjects were not diagnosed for BR ...
Sep 01, 2009 |
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More women choosing preventive double mastectomies
When health care worker Kathy Hajopoulos decided in 2006 to remove both her breasts when she was diagnosed with cancer in one, she became part of a growing class of women making that same decision.
Oct 23, 2009 |
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Annual screening with breast ultrasound or MRI could benefit some women
Results of a large-scale clinical trial presented today at the annual meeting of the Radiological Society of North America (RSNA) provide the first strong evidence of the benefit of annual screening ultrasound for women with ...
Dec 02, 2009 |
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Mutation of BRCA gene influences women's views of preventive mastectomy
Women whose cells harbor harmful mutations in the BRCA genes are likely to view preventive mastectomy as the best way to reduce their risk and fears of developing breast cancer, despite other, less drastic options available. ...
Mar 09, 2009 |
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BRCA1
BRCA1 ( /ˈbrækə/; breast cancer 1, early onset) is a human caretaker gene that produces a protein called breast cancer type 1 susceptibility protein, responsible for repairing DNA. The first evidence for the existence of the gene was provided by the King laboratory at UC Berkeley in 1990. The gene was later cloned in 1994 by scientists at Myriad Genetics.
BRCA1 is expressed in the cells of breast and other tissue, where it helps repair damaged DNA, or destroy cells if DNA cannot be repaired. If BRCA1 itself is damaged, damaged DNA is not repaired properly and this increases risks for cancers.
The protein encoded by the BRCA1 gene combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). The BRCA1 protein associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. Thus, this protein plays a role in transcription, DNA repair of double-stranded breaks ubiquitination, transcriptional regulation as well as other functions.
For more information about BRCA1, read the full article at
Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
