Researchers at Yale University, New Haven, have optimized a polymer-based mRNA vehicle for targeted lung delivery and demonstrated the potential of the platform for mucosal vaccination against respiratory pathogens.
It is now possible to deliver therapeutics based on short interfering RNAs to hepatocytes; however, new delivery solutions are necessary to target additional organs. In a new report now published in Nature Biotechnology, ...
The homotrimeric spike glycoprotein (S) from SARS-CoV-2, particularly its S2 subunit, is a fusion protein extraordinaire. It can fuse viral particles to cells and also fuse cells to cells to create multifarious syncytia among ...
Transposable elements, or jumping genes, are now known to be responsible for many human diseases. Keeping them repressed by methylation, RNA binding, or the attentions of the innate immune system is a full-time jump for ...
Heme is an essential part of the protein hemoglobin, which colors human blood red. Heme also is crucial for cytochrome proteins, which power the cell. Humans, animals, plants and bacteria all use heme.
Molecular & Computational biology
Dec 20, 2021
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338
Nanoparticles are promising drug delivery tools, offering the ability to administer drugs directly to a specific part of the body and avoid the awful side effects so often seen with chemotherapeutics.
Bio & Medicine
Nov 25, 2020
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400
Researchers have developed a way to prop up a struggling immune system to enable its fight against sepsis, a deadly condition resulting from the body's extreme reaction to infection.
Bio & Medicine
Jan 6, 2020
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325
Researchers hope to design a new generation of drugs against an array of deadly diseases. The task, however, is costly, arduous and often ineffective. One of the key challenges is understanding a particular class of proteins ...
Biochemistry
Apr 5, 2017
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109
Researchers from North Carolina State University have confirmed that blood vessel-like structures found in an 80 million-year-old hadrosaur fossil are original to the animal, and not biofilm or other contaminants. Their findings ...
Archaeology
Dec 1, 2015
9
4173
A detailed comparison of DNA and RNA in human cells has uncovered a surprising number of cases where the corresponding sequences are not, as has long been assumed, identical. The RNA-DNA differences generate proteins that ...
Biotechnology
May 19, 2011
2
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