News tagged with bisphosphonates
Bone drug Zometa flops in breast cancer study
(AP) -- Doctors are reporting a stunning setback for a promising new approach for fighting breast cancer.
Dec 09, 2010 |
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FDA warns of fractures with osteoporosis drugs
(AP) -- Government health officials warned doctors and patients Wednesday about an increased risk of thigh fractures with a widely used group of bone-strengthening drugs.
Medicine & Health / Medications
Oct 13, 2010 |
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Long-term use of osteoporosis drugs associated with unusual fractures
(PhysOrg.com) -- Most hip fractures due to osteoporosis follow a pattern: the patient falls, and the bones around the hip joint shatter into pieces. But 2 to 3 years ago, orthopedic surgeons began seeing an increase in unusual ...
Medicine & Health / Medications
Sep 21, 2010 |
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Benefits of osteoporosis treatments outweigh possible risk of rare femoral fractures
The occurrence of an unusual type of fracture of the femur, or the thigh bone, is very low in patients with osteoporosis, including those treated with the drug family known as bisphosphonates, according to a new study led ...
Medicine & Health / Medical research
Mar 24, 2010 |
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Quantity vs. quality: Long-term use of bone-building osteoporosis drugs
Bisphosphonate treatments, proven to enhance bone density and reduce fracture incidence in post-menopausal women, may adversely affect bone quality and increase risk of atypical fractures of the femur when used for four or ...
Medicine & Health / Medical research
Mar 10, 2010 |
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Common osteoporosis drugs are associated with a decrease in risk of breast cancer
Women who take some types of bone-building drugs used to prevent and treat osteoporosis may be at lower risk of breast cancer, according to a study by U.S. researchers published today in the British Journal of Cancer.
Mar 02, 2010 |
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Yeast unravels effects of chemotherapy drugs
Until now, the mode of action of nitrogen-containing bisphosphonate (N-BP) cancer drugs, used to relieve bone pain and to prevent skeletal complications in bone metastasis, has been almost entirely unknown. Researchers writing ...
Sep 09, 2009 |
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Buyer beware: Estrogen supplements not as effective as claimed
Dietary supplements claiming to help postmenopausal women with bone health may not be doing what they say, according to new research from Purdue University.
Sep 02, 2009 |
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Denosumab increases bone density, cuts fracture risk in prostate cancer survivors
Twice-yearly treatment with denosumab, a new targeted therapy to stop bone loss, increased bone density and prevented spinal fractures in men receiving androgen-deprivation therapy for prostate cancer. The report from an ...
Aug 11, 2009 |
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Osteoporosis drug may save lives by strengthening immune system
An osteoporosis drug proven to save lives after hip fractures may do so by strengthening the body's immune system, according to geriatrics researchers at Duke University Medical Center.
Medicine & Health / Diseases, Conditions, Syndromes
Jul 15, 2009 |
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New drug agent knocks out multiple enzymes in cancer pathway
A team of 24 researchers from the U.S., Europe, Taiwan and Japan and led by University of Illinois scientists has engineered a new anti-cancer agent that is about 200 times more active in killing tumor cells ...
Mar 25, 2009 |
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Common bone drugs may reduce colon cancer risk
An international team of researchers has found that the use of bisphosphonates - drugs already taken by millions of healthy women to prevent bone-loss - for more than one year was associated with a 50 percent reduction in ...
Feb 16, 2011 |
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Journal of Dental Research releases large studies on osteonecrosis of the jaw
Osteonecrosis of the jaw (ONJ) is a debilitating bone condition that affects the jaws and occurs as a result of reduced local blood supply to the bone. The literature in this area has been severely limited since most investigations ...
Medicine & Health / Diseases, Conditions, Syndromes
Feb 11, 2011 |
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Taking a break from osteoporosis drugs can protect bones
Taking time off from certain osteoporosis drugs may be beneficial to bone health, according to a study conducted at Loyola University Health System. Researchers found that bone density remained stable for three years in patients ...
Medicine & Health / Medical research
Nov 18, 2010 |
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Long term use of oral bisphosphonates may double risk of esophageal cancer
People who take oral bisphosphonates for bone disease over five years may be doubling their risk of developing oesophageal cancer (cancer of the gullet), according to a new study published in the British Medical Journal today.
Sep 02, 2010 |
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Bisphosphonate
In pharmacology, bisphosphonates (also called diphosphonates) are a class of drugs that prevent the loss of bone mass, used to treat osteoporosis and similar diseases.
Bone has constant turnover, and is kept in balance (homeostasis) by osteoblasts creating bone and osteoclasts digesting bone. Bisphosphonates inhibit the digestion of bone by osteoclasts.
Osteoclasts also have constant turnover and normally destroy themselves by a process called cell suicide (apoptosis). Bisphosphonates encourage osteoclasts to undergo apoptosis.
The uses of bisphosphonates include the prevention and treatment of osteoporosis, osteitis deformans ("Paget's disease of bone"), bone metastasis (with or without hypercalcaemia), multiple myeloma, primary hyperparathyroidism, osteogenesis imperfecta and other conditions that feature bone fragility.
For more information about Bisphosphonate, read the full article at
Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
