News tagged with bisphosphonates
USC dentist links Fosomax-type drugs to jaw necrosis
Researchers at the University Of Southern California, School Of Dentistry release results of clinical data that links oral bisphosphonates to increased jaw necrosis. The study is among the first to acknowledge that even short-term ...
Medicine & Health / Medical research
Jan 01, 2009 |
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New drug agent knocks out multiple enzymes in cancer pathway
A team of 24 researchers from the U.S., Europe, Taiwan and Japan and led by University of Illinois scientists has engineered a new anti-cancer agent that is about 200 times more active in killing tumor cells ...
Mar 25, 2009 |
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Space-related radiation research could help reduce fractures in cancer survivors
A research project looking for ways to reduce bone loss in astronauts may yield methods of improving the bone health of cancer patients undergoing radiation treatment.
Medicine & Health / Medical research
Sep 15, 2009 |
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Common bone drugs may reduce colon cancer risk
An international team of researchers has found that the use of bisphosphonates - drugs already taken by millions of healthy women to prevent bone-loss - for more than one year was associated with a 50 percent reduction in ...
Feb 16, 2011 |
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Quantity vs. quality: Long-term use of bone-building osteoporosis drugs
Bisphosphonate treatments, proven to enhance bone density and reduce fracture incidence in post-menopausal women, may adversely affect bone quality and increase risk of atypical fractures of the femur when used for four or ...
Medicine & Health / Medical research
Mar 10, 2010 |
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Long-term use of osteoporosis drugs associated with unusual fractures
(PhysOrg.com) -- Most hip fractures due to osteoporosis follow a pattern: the patient falls, and the bones around the hip joint shatter into pieces. But 2 to 3 years ago, orthopedic surgeons began seeing an increase in unusual ...
Medicine & Health / Medications
Sep 21, 2010 |
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Taking a break from osteoporosis drugs can protect bones
Taking time off from certain osteoporosis drugs may be beneficial to bone health, according to a study conducted at Loyola University Health System. Researchers found that bone density remained stable for three years in patients ...
Medicine & Health / Medical research
Nov 18, 2010 |
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Some bisphosphonates users unfamiliar with drug's possible side effects on oral health
People undergoing bisphosphonate therapy to prevent or treat osteoporosis (a thinning of the bones) may be unfamiliar with the drug and possible adverse side effects on oral health, according to a study in the May issue ...
May 26, 2010 |
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Long term use of oral bisphosphonates may double risk of esophageal cancer
People who take oral bisphosphonates for bone disease over five years may be doubling their risk of developing oesophageal cancer (cancer of the gullet), according to a new study published in the British Medical Journal today.
Sep 02, 2010 |
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FDA warns of fractures with osteoporosis drugs
(AP) -- Government health officials warned doctors and patients Wednesday about an increased risk of thigh fractures with a widely used group of bone-strengthening drugs.
Medicine & Health / Medications
Oct 13, 2010 |
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Osteoporosis drug may save lives by strengthening immune system
An osteoporosis drug proven to save lives after hip fractures may do so by strengthening the body's immune system, according to geriatrics researchers at Duke University Medical Center.
Medicine & Health / Diseases, Conditions, Syndromes
Jul 15, 2009 |
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Yeast unravels effects of chemotherapy drugs
Until now, the mode of action of nitrogen-containing bisphosphonate (N-BP) cancer drugs, used to relieve bone pain and to prevent skeletal complications in bone metastasis, has been almost entirely unknown. Researchers writing ...
Sep 09, 2009 |
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Bisphosphonate
In pharmacology, bisphosphonates (also called diphosphonates) are a class of drugs that prevent the loss of bone mass, used to treat osteoporosis and similar diseases.
Bone has constant turnover, and is kept in balance (homeostasis) by osteoblasts creating bone and osteoclasts digesting bone. Bisphosphonates inhibit the digestion of bone by osteoclasts.
Osteoclasts also have constant turnover and normally destroy themselves by a process called cell suicide (apoptosis). Bisphosphonates encourage osteoclasts to undergo apoptosis.
The uses of bisphosphonates include the prevention and treatment of osteoporosis, osteitis deformans ("Paget's disease of bone"), bone metastasis (with or without hypercalcaemia), multiple myeloma, primary hyperparathyroidism, osteogenesis imperfecta and other conditions that feature bone fragility.
For more information about Bisphosphonate, read the full article at
Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
