News tagged with binding protein
Study finds a weak spot on deadly ebolavirus
Scientists from The Scripps Research Institute and the US Army's Medical Research Institute of Infectious Diseases have isolated and analyzed an antibody that neutralizes Sudan virus, a major species of ebolavirus ...
Nov 21, 2011 |
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The splice of life: Proteins cooperate to regulate gene splicing
Understanding how RNA binding proteins control the genetic splicing code is fundamental to human biology and disease – much like editing film can change a movie scene. Abnormal variations in splicing ...
Feb 16, 2012 |
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1930s drug slows tumor growth
Drugs sometimes have beneficial side effects. A glaucoma treatment causes luscious eyelashes. A blood pressure drug also aids those with a rare genetic disease. The newest surprise discovered by researchers at the Johns ...
Medicine & Health / Medications
Nov 06, 2009 |
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Genetically engineered mice don't get obese (w/Podcast)
Obesity and gallstones often go hand in hand. But not in mice developed at Washington University School of Medicine in St. Louis. Even when these mice eat high-fat diets, they don't get fat, but they do develop ...
Medicine & Health / Medical research
May 07, 2009 |
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Scorpion venom with nanoparticles slows spread of brain cancer
By combining nanoparticles with a scorpion venom compound already being investigated for treating brain cancer, University of Washington researchers found they could cut the spread of cancerous cells by 98 ...
Nanotechnology / Bio & Medicine
Apr 16, 2009 |
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Human cells build protein cages to trap invading Shigella
In research on the never-ending war between pathogen and host, scientists at the Pasteur Institute in Paris have discovered a novel defensive weapon, a cytoskeletal protein called septin, that humans cells deploy to cage ...
Dec 04, 2011 |
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Worm study yields insights on humans, parasites and iron deficiency
Using a tiny bloodless worm, University of Maryland Associate Professor Iqbal Hamza and his team have discovered a large piece in the puzzle of how humans, and other organisms safely move iron around in the ...
May 26, 2011 |
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Meningitis bacteria dress up as human cells to evade our immune system
(PhysOrg.com) -- The way in which bacteria that cause bacterial meningitis mimic human cells to evade the body's innate immune system has been revealed by researchers at the University of Oxford and Imperial ...
Medicine & Health / Medical research
Feb 18, 2009 |
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Key regulators for biofilm development discovered
They can be found everywhere -- organized communities of bacteria sticking to surfaces both inside and outside the body. These biofilms are responsible for some of the most virulent, antibiotic-resistant infections in humans; ...
Jun 24, 2011 |
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New laser technique opens doors for drug discovery
A new laser technique has demonstrated that it can measure the interactions between proteins tangled in a cell's membrane and a variety of other biological molecules. These extremely difficult measurements ...
Mar 15, 2011 |
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Researchers pinpoint how one cancer gene functions
For several decades, researchers have been linking genetic mutations to diseases ranging from cancer to developmental abnormalities. What hasn't been clear, however, is how the body's genome sustains such destructive glitches ...
Feb 02, 2011 |
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Protein assassin: Scientists find that the unfolded end of a protein can kill E. coli-like bacteria selectively
When bacteria wage a turf war, some of the combatants have an extra weapon. Certain strains of the bacteria E. coli produce proteins that kill competing E. coli and other like microbes, and researchers from Newcastle Uni ...
Feb 23, 2012 |
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Fluorescent compounds make tumors glow
A series of novel imaging agents could light up tumors as they begin to form - before they turn deadly - and signal their transition to aggressive cancers.
Apr 29, 2010 |
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All tied up: Tethered protein provides long-sought answer
The tools of biochemistry have finally caught up with lactose repressor protein. Biologists from Rice University in Houston and the University of Florence in Italy this week published new results about "lac ...
Sep 22, 2009 |
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Chemists discover how antiviral drugs bind to and block flu virus
Antiviral drugs block influenza A viruses from reproducing and spreading by attaching to a site within a proton channel necessary for the virus to infect healthy cells, according to a research project led ...
Feb 03, 2010 |
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Carrier protein
Carrier proteins are proteins that transport a specific substance or group of substances through intracellular compartments or in extracellular fluids (e.g. in the blood) or else across the cell membrane. Some of the carriers are water-soluble proteins that may or may not interact with biological membranes, such as some transporters of small hydrophobic molecules, whereas others are integral transmembrane proteins.
Carrier proteins transport substances out of or into the cell by facilitated diffusion and active transport. Each carrier protein is designed to recognize only one substance or one group of very similar substances. The molecule or ion to be transported (the substrate) must first bind at a binding site at the carrier molecule, with a certain binding affinity. Following binding, and while the binding site is facing, say, outwards, the carrier will capture or occlude (take in and retain) the substrate within its molecular structure and cause an internal translocation, so that it now faces the other side of the membrane. The substrate is finally released at that site, according to its binding affinity there. All steps are reversible.
For example:
For more information about Carrier protein, read the full article at
Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
