A new imaging technique developed by engineers at Washington University in St. Louis can give scientists a much closer look at fibril assemblies—stacks of peptides that include amyloid beta, most notably associated with ...
Bio & Medicine
23 hours ago
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28
Scientists from Rice University are using fluorescence lifetime to shed new light on a peptide associated with Alzheimer's disease, which the Centers for Disease Control and Prevention estimates will affect nearly 14 million ...
Biochemistry
Jan 25, 2023
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32
Inside a living cell, proteins and other molecules are often tightly packed together. These dense clusters can be difficult to image because the fluorescent labels used to make them visible can't wedge themselves in between ...
Bio & Medicine
Aug 29, 2022
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138
Neurodegenerative diseases like Alzheimer's disease or Parkinson's disease are caused by folding errors (misfolding) in proteins or peptides, i.e. by changes in their spatial structure. This is the result of minute deviations ...
Biochemistry
Jul 20, 2022
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15
Researchers have shown that aggregation of amyloid-beta, one of two key proteins implicated in Alzheimer's disease, causes cells to overheat and "fry like eggs."
Biochemistry
May 31, 2022
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252
A probe invented at Rice University that lights up when it binds to a misfolded amyloid beta peptide—the kind suspected of causing Alzheimer's disease—has identified a specific binding site on the protein that could facilitate ...
Biochemistry
Oct 19, 2017
0
255
A metallic molecule being studied at Rice University begins to glow when bound to amyloid protein fibrils of the sort implicated in Alzheimer's disease. When triggered with ultraviolet light, the molecule glows much brighter, ...
Biochemistry
Jul 7, 2016
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12
Scientists at UC Santa Barbara and several other institutions have found laboratory evidence that a cluster of peptides may be the toxic agent in Alzheimer's disease. Scientists say the discovery may lead to new drugs for ...
Biochemistry
Jul 1, 2009
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0
(PhysOrg.com) -- Which modules of the tau protein, in neurons of Alzheimer disease patients, may act in a destructive manner were investigated by researchers from the Max Planck Institute for Biophysical Chemistry (Göttingen) ...
Feb 17, 2009
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0
Stains that make specific components of a live cell light up under a microscope have become powerful tools for detecting disease and monitoring biological processes, but the choice of available stains is severely limited ...
Biochemistry
Dec 12, 2022
0
48
Amyloid beta (Aβ or Abeta) is a peptide of 39–43 amino acids that appear to be the main constituent of amyloid plaques in the brains of Alzheimer's disease patients. Similar plaques appear in some variants of Lewy body dementia and in inclusion body myositis, a muscle disease. Aβ also forms aggregates coating cerebral blood vessels in cerebral amyloid angiopathy. These plaques are composed of a tangle of regularly ordered fibrillar aggregates called amyloid fibers, a protein fold shared by other peptides such as prions associated with protein misfolding diseases. Research on laboratory rats suggest that the two-molecule, soluble form of the peptide is a causative agent in the development of Alzheimer's and that the two-molecule form is the smallest synaptotoxic species of soluble amyloid beta oligomer
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