Researchers design switch-like proteins inspired by transistors

Scientists from the University of Washington have designed custom proteins that can switch between two fully structured conformations. By coupling this molecular motion with a binding event, these proteins serve as biological ...

Deciphering the molecular dynamics of complex proteins

Which structures do complex proteins adopt in solution? Konstanz biophysicists answer this question using the example of ubiquitin dimers as well as a new combination of high-resolution NMR spectroscopy and sophisticated ...

Deep learning for new protein design

The key to understanding proteins—such as those that govern cancer, COVID-19, and other diseases—is quite simple: Identify their chemical structure and find which other proteins can bind to them. But there's a catch.

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