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Scientists reveal key mechanism governing nicotine addiction

Scientists from the Florida campus of The Scripps Research Institute have identified a pathway in the brain that regulates an individual's vulnerability to the addictive properties of nicotine. The findings suggest a new ...

Medicine & Health / Medical research

created Jan 30, 2011 | popularity 4.7 / 5 (17) | comments 2 | with audio podcast

Compulsive eating shares addictive biochemical mechanism with cocaine, heroin abuse: study

In a newly published study, scientists from The Scripps Research Institute have shown for the first time that the same molecular mechanisms that drive people into drug addiction are behind the compulsion to overeat, pushing ...

Medicine & Health / Neuroscience

created Mar 28, 2010 | popularity 4.5 / 5 (10) | comments 6 | with audio podcast

Dopamine enhances expectation of pleasure in humans

(PhysOrg.com) -- Enhancing the effects of the brain chemical dopamine influences how people make life choices by affecting expectations of pleasure, according to new research from the UCL Institute of Neurology.

Medicine & Health / Neuroscience

created Nov 12, 2009 | popularity 4.2 / 5 (10) | comments 0

How heroin works: Imaging opioid receptors in the brain

(Phys.org) -- Researchers and doctors have gleaned new clues to the molecular mechanisms behind some of the most addictive substances in the world, thanks to two new studies that uncovered the structures of ...

Chemistry / Biochemistry

created Apr 25, 2012 | popularity 5 / 5 (1) | comments 0 | with audio podcast

Scientists create vaccine against heroin high

Researchers at The Scripps Research Institute have developed a highly successful vaccine against a heroin high and have proven its therapeutic potential in animal models.

Chemistry / Biochemistry

created Jul 20, 2011 | popularity 4 / 5 (9) | comments 8 | with audio podcast

Scientists crack molecular code regulating neuronal excitability

A key question in protein biochemistry is how proteins recognize "correct" interaction partners in a sea of cellular factors. Nowhere is that more critical to know than in the brain, where interactions governing ...

Medicine & Health / Medical research

created Mar 22, 2011 | popularity 5 / 5 (2) | comments 0 | with audio podcast

Miniature 'wearable' PET scanner ready for use (w/ Video)

(PhysOrg.com) -- Scientists from the U.S. Department of Energy's (DOE) Brookhaven National Laboratory, Stony Brook University, and collaborators have demonstrated the efficacy of a "wearable," portable PET ...

Medicine & Health / Medical research

created Mar 13, 2011 | popularity 4.7 / 5 (3) | comments 2 | with audio podcast

Genetic makeup and duration of abuse reduce the brain's neurons in drug addiction

A study conducted at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory demonstrated that drug addicted individuals who have a certain genetic makeup have lower gray matter density – ...

Medicine & Health / Psychology & Psychiatry

created Mar 07, 2011 | popularity 2 / 5 (2) | comments 0 | with audio podcast

Binge eaters' dopamine levels spike at sight, smell of food

(PhysOrg.com) -- A brain imaging study at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory reveals a subtle difference between ordinary obese subjects and those who compulsively overeat, ...

Medicine & Health / Medical research

created Feb 28, 2011 | popularity 5 / 5 (2) | comments 0 | with audio podcast

Vaccine blocks cocaine high in mice

Researchers have produced a lasting anti-cocaine immunity in mice by giving them a safe vaccine that combines bits of the common cold virus with a particle that mimics cocaine.

Medicine & Health / Medical research

created Jan 04, 2011 | popularity 3.5 / 5 (2) | comments 0 | with audio podcast

Unlocking the secrets of our compulsions

Researchers have shed new light on dopamine's role in the brain's reward system, which could provide insight into impulse control problems associated with addiction and a number of psychiatric disorders.

Medicine & Health / Medical research

created Dec 08, 2010 | popularity 4.7 / 5 (3) | comments 0 | with audio podcast

A thirst for excitement is hidden in your genes

Sensation seeking -- the urge to do exciting things -- has been linked to dopamine, a chemical that carries messages in your brain. For a new study published in Psychological Science, a journal of the Association for Psycho ...

Medicine & Health / Psychology & Psychiatry

created Oct 05, 2010 | popularity 4 / 5 (3) | comments 0 | with audio podcast

Specific brain areas for sex, money

A team of French researchers headed by Jean-Claude Dreher of the Centre de Neuroscience Cognitive in Lyon, France, has provided the first evidence that the orbitofrontal cortex (located in the anterior ventral ...

Medicine & Health / Neuroscience

created Oct 01, 2010 | popularity 5 / 5 (8) | comments 3 | with audio podcast

Milkshake like cocaine for overeaters: Imaging shows the powerful impact food has on the brain

Millions of overweight Americans consider food the enemy. And according to new research, this enemy plays devious mind games.

Medicine & Health / Neuroscience

created Sep 30, 2010 | popularity 5 / 5 (5) | comments 1 | with audio podcast

Ritalin improves brain function, task performance in cocaine abusers

(PhysOrg.com) -- Brain-scanning study shows Ritalin improves impaired brain function in people addicted to cocaine, implying it could play a role in facilitating recovery from addiction.

Medicine & Health / Medical research

created Sep 07, 2010 | popularity 4.8 / 5 (5) | comments 0 | with audio podcast

Addiction

The term "addiction" is used in many contexts to describe an obsession, compulsion, or excessive psychological dependence, such as: drug addiction (e.g. alcoholism), video game addiction, crime, money, work addiction, compulsive overeating, problem gambling, computer addiction, nicotine addiction, pornography addiction, etc.

In medical terminology, an addiction is a chronic neurobiologic disorder that has genetic, psychosocial, and environmental dimensions and is characterized by one of the following: the continued use of a substance despite its detrimental effects, impaired control over the use of a drug (compulsive behavior), and preocupation with a drug's use for non-therapeutic purposes (i.e. craving the drug). Addiction is often accompanied the presence of deviant behaviors (for instance stealing money and forging prescriptions) that are used to obtain a drug.

Tolerance to a drug and physical dependence are not defining characteristics of addiction, although they typically accompany addiction to certain drugs. Tolerance is a pharmacologic phenomenon where the dose of a medication needs to be continually increase in order to maintain its desired effects. For instance, individuals with severe chronic pain taking opiate medications (like morphine) will need to continually increase the dose in order to maintain the drug's analgesic (pain-relieving) effects. Physical dependence is also a pharmacologic property and means that if a certain drug is abruptly discontinued, an individual will experience certain characteristic withdrawal signs and symptoms. Many drugs used for therapeutic purposes produce withdrawal symptoms when abruptly stopped, for instance oral steroids, certain antidepressants, benzodiazepines, and opiates.

However, common usage of the term addiction has spread to include psychological dependence. In this context, the term is used in drug addiction and substance abuse problems, but also refers to behaviors that are not generally recognized by the medical community as problems of addiction, such as compulsive overeating.

The term addiction is also sometimes applied to compulsions that are not substance-related, such as problem gambling and computer addiction. In these kinds of common usages, the term addiction is used to describe a recurring compulsion by an individual to engage in some specific activity, despite harmful consequences, as deemed by the user himself to his or her individual health, mental state or social life.

For more information about Addiction, read the full article at Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.

Related topics: brain , alcohol , nicotine