Women are far more likely than men to get autoimmune diseases, when an out-of-whack immune system attacks their own bodies—and new research may finally explain why.
More than 2,500 genes exhibit significant sex differences in expression in mouse alveolar type II cells (AT2s), which are important for keeping the lungs functioning, potentially explaining sex biases in the prevalence and ...
In most mammals, females have two X chromosomes and males have one X and one Y chromosome in each of their cells. To avoid a double dose of X-linked genes in females, one of the Xs is silenced early in the developmental process. ...
RNA (ribonucleic acid) plays many roles in human health, and now a study in the journal Nature offers powerful evidence that RNA could also be a viable target for drug development. This work, led by researchers at Massachusetts ...
The cells of female mammals have a dosage problem, because they have twice as many X chromosomes as are needed in the body. Consequently, one of them is randomly selected and switched off already during early embryonic development. ...
In one of the mysteries of mammalian development, every cell in the early female embryo shuts down one of its two copies of the X chromosome, leaving just one functional. For years, the mechanics behind this X chromosome ...
Researchers at Massachusetts General Hospital (MGH) have uncovered new clues that add to the growing understanding of how female mammals, including humans, 'silence' one X chromosome. Their new study, published in Molecular ...
Researchers at Massachusetts General Hospital (MGH) have solved a mystery that has long puzzled scientists: How do the bodies of female humans and all other mammals decide which of the two X chromosomes it carries in each ...
While scientists still don't fully understand the diverse nature of RNA molecules, it is believed that the proteins binding to them, called RNA-binding proteins, are associated with many types of disease formation. Research ...
Researchers at the European Molecular Biology Laboratory (EMBL) in Heidelberg and Institut Curie in Paris have shown that the protein SPEN plays a crucial role in the process of X-chromosome inactivation, whereby female mammalian ...
