Search results for topoisomerase ii

Biochemistry Mar 28, 2024

Biochemists discover first new antibacterial class in decades

Vanderbilt biochemists are part of a team taking a stride toward the development of antibacterials to treat uncomplicated urinary tract infections, a pervasive bacterial infection that affects 50%–60% of women in their ...

Biochemistry Jun 30, 2023

Potent new compound has breakthrough potential for parasitic sleeping sickness and Chagas treatment

Scientists have discovered a new class of compound that is potentially active against trypanosome parasites that cause human African trypanosomiasis (or sleeping sickness) and Chagas disease.

Cell & Microbiology Mar 2, 2023

Researchers find mechanism that ensures correct DNA segregation in cell division

A research team led by Dr. Gary Ying Wai Chan from the School of Biological Sciences at The University of Hong Kong (HKU), has uncovered a new mechanism that ensures correct DNA segregation in cell division, where improper ...

Biochemistry Jan 30, 2023

Optical tweezers untangle chemotherapy agent's impact on DNA

New Cornell research is providing a fresh view into the ways a common chemotherapy agent, etoposide, stalls and poisons the essential enzymes that allow cancer cells to flourish.

Evolution May 27, 2022

An arms race that plays out in a single genome

Biological arms races are commonplace in nature. Cheetahs, for example, have evolved a sleek body form that lends itself to rapid running, enabling them to feast upon similarly speedy gazelles, the fastest of which may evade ...

Cell & Microbiology Jan 20, 2022

Researchers identify replication and transcription machinery for Ranaviruses

Members of the genus Ranavirus (family iridoviridae) are nucleo-cytoplasmic large DNA viruses (NCLDVs) isolated from aquatic animals including reptiles, amphibians, and bony fish. They are promiscuous pathogens that pose ...

Molecular & Computational biology Sep 30, 2021

Linker histones tune the length and shape of chromosomes

Human life hinges on the ability of our cells to cram six feet of DNA into a 10-micron nucleus—equivalent to fitting a mile of string inside one green pea. But stuffing genes into cramped quarters is only half the battle. ...

Cell & Microbiology Sep 8, 2021

Experimentally reconstructing the reorganization of chromosomal DNA during mitosis

Two RIKEN researchers have discovered how, during cell division, one enzyme helps facilitate the tightly coordinated reorganization of chromosomal DNA into compact structures that can be evenly divided amongst the two resulting ...

Cell & Microbiology Mar 4, 2021

Scientists explore the action mechanism of a new antibiotic

Scientists from Skoltech and MSU have investigated antibiotic nybomycin that could prove effective against bacteria resistant to other antibiotics. Their research was published in the journal Antimicrobial Agents and Chemotherapy.

Cell & Microbiology Oct 28, 2019

Completing DNA synthesis

The final stage of DNA replication—"termination"—occurs when two DNA copy machines advance upon each other and unwind the final stretch of DNA. This process occurs about 60,000 times per human cell cycle and is crucial ...

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