http://phys.org/ en-us Phys.org internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. (PhysOrg.com) -- Physicists at the University of California, Santa Cruz, are working with medical researchers at Loma Linda University Medical Center to develop a new imaging technology to guide proton therapy for cancer treatment. http://phys.org/news224495897.html Physics Fri, 13 May 2011 09:10:01 EST news224495897 Like DNA, centrioles need to duplicate only once per cell cycle. Rogers et al. uncover a long-sought mechanism that limits centriole copying, showing that it depends on the timely demolition of a protein that spurs the organelles' replication. http://phys.org/news152194390.html Biology Mon, 26 Jan 2009 12:13:37 EST news152194390 A new study appearing in The Prostate has found that certain measles virus vaccine strain derivatives, including a strain known as MV-CEA, may prove to be an effective treatment for patients with advanced prostate cancer. The findings show that this type of treatment, called virotherapy, can effectively infect, replicate in and kill prostate cancer cells. http://phys.org/news151764972.html Medicine & Health Wed, 21 Jan 2009 12:56:45 EST news151764972 Researchers at Mayo Clinic have found that the experimental drug they are testing to treat a deadly form of thyroid cancer turns on a powerful tumor suppressor capable of halting cell growth. Few other cancer drugs have this property, they say. http://phys.org/news151652715.html Medicine & Health Tue, 20 Jan 2009 05:45:43 EST news151652715 (PhysOrg.com) -- Dartmouth Medical School researchers have found two proteins that work in concert to ensure proper chromosome segregation during cell division. Their study is in the January 2009 issue of the journal Nature Cell Biology. http://phys.org/news151343442.html Medicine & Health Fri, 16 Jan 2009 15:50:42 EST news151343442 (PhysOrg.com) -- Current treatments for pancreatic cancer have failed to effectively manage the disease and improve the grim survival rate. A Northeastern University study found that the thick layer of mucin covering the tumor cells acts as a barrier to chemotherapy drugs, thus it is responsible for the diminished anti-tumor effect of popular treatment drugs such as 5-FU (fluorouracil). http://phys.org/news151260469.html Medicine & Health Thu, 15 Jan 2009 16:47:49 EST news151260469 Variations in mismatch repair genes can help predict treatment response and prognosis in patients with pancreatic cancer, according to research from The University of Texas M. D. Anderson Cancer Center presented today in advance of the American Society of Clinical Oncology (ASCO) Gastrointestinal Cancers Symposium. http://phys.org/news151141502.html Medicine & Health Wed, 14 Jan 2009 07:45:02 EST news151141502 Findings from a study conducted in mice, published in the open access journal PLoS Medicine next week, provide new insights into how an effective immune response to brain tumors could potentially be brought about in humans. http://phys.org/news151053609.html Medicine & Health Tue, 13 Jan 2009 07:20:09 EST news151053609 A new study sheds light on a little understood biological process called quiescence, which enables blood-forming stem cells to exist in a dormant or inactive state in which they are not growing or dividing. According to the study's findings, researchers identified the genetic pathway used to maintain a cell's quiescence, a state that allows bone marrow cells to escape the lethal effects of standard cancer treatments. http://phys.org/news150726406.html Biology Fri, 09 Jan 2009 12:26:46 EST news150726406 Molecules of sugar sitting on the surface of cancer cells are keys to the development of a new vaccine aimed at both treating and stopping the spread of certain types of cancers called carcinomas, which include prostate, breast, ovarian and lung, among others. Armed with a new two-year grant for $600,000 from the Gateway for Cancer Research, an Illinois-based philanthropic foundation, immunologist Alessandra Franco, M.D., Ph.D., and her co-workers at the Moores Cancer Center at the University of California, San Diego are hoping to develop a low-cost immunotherapy for prostate carcinoma that may also have use against a variety of other carcinomas as well. http://phys.org/news150657878.html Medicine & Health Thu, 08 Jan 2009 17:24:38 EST news150657878 Cancer and cell biology experts at the University of Cincinnati (UC) have identified a new tumor suppressor that may help scientists develop more targeted drug therapies to combat lung cancer. http://phys.org/news150389078.html Medicine & Health Mon, 05 Jan 2009 14:44:38 EST news150389078 Researchers at The Ohio State University Comprehensive Cancer Center have discovered that a molecule implicated in leukemia and lung cancer is also important in muscle repair and in a muscle cancer that strikes mainly children. http://phys.org/news149860013.html Medicine & Health Tue, 30 Dec 2008 11:46:53 EST news149860013 In recent years HIFU has been widely used for the treatment of solid tumors, such as liver tumor, bone tumor, and breast cancer. The mechanism for therapeutic actions of HIFU includes thermal effects and non-thermal effects with the latter dominated by cavitational effects. Adjusting acoustic parameters of pulsed high intensity focused ultrasound (PHIFU) can control thermal effects and non-thermal effects; short duty cycle and high intensity favors the occurrence of cavitation. Ultrasound contrast agent (UCA) can enhance cavitational effects. Lesions caused by non-thermal effects have characteristic pathological changes quite different from those of thermal lesions. http://phys.org/news149769705.html Medicine & Health Mon, 29 Dec 2008 10:41:45 EST news149769705 UC Davis Cancer Center researchers report today the discovery of a molecule that targets glioblastoma, a highly deadly form of cancer. The finding, which is published in the January 2009 issue of the European Journal of Nuclear Medicine and Molecular Imaging, provides hope for effectively treating an incurable cancer. http://phys.org/news149769509.html Medicine & Health Mon, 29 Dec 2008 10:38:29 EST news149769509 Researchers have discovered two enzymes that, when combined, could be involved in the earliest stages of cancer. Manipulating these enzymes genetically might lead to targeted therapies aimed at slowing or preventing the onset of tumors. http://phys.org/news149345232.html Medicine & Health Wed, 24 Dec 2008 12:47:12 EST news149345232 Researchers at Thomas Jefferson University have found that a lower dose of fractionated stereotactic radiotherapy for acoustic neuromas results in better hearing preservation and has the same tumor local control rate as a higher dose of therapy. The study appeared online in the International Journal of Radiation Oncology*Biology*Physics. http://phys.org/news148736594.html Medicine & Health Wed, 17 Dec 2008 11:43:14 EST news148736594 A breakthrough technique that allows scientists to view individually-labeled tumor cells as they move about in real time in a live mouse may enable scientists to develop microenvironment-specific drugs against cancer, researchers report at the American Society for Cell Biology (ASCB) 48th Annual Meeting, Dec. 13-17, 2008 in San Francisco. http://phys.org/news148571378.html Medicine & Health Mon, 15 Dec 2008 13:49:38 EST news148571378 Researchers at Georgetown University Medical Center have found a gene they say is inactivated in two aggressive cancers – malignant melanoma, a form of skin cancer, and glioblastoma multiforme, a lethal brain tumor. They add that because this gene, known as PTPRD, has recently been found to be inactivated in several other cancers as well, their discovery suggests that PTPRD may play a tumor suppressor role in a wide variety of different cancers. http://phys.org/news148543933.html Medicine & Health Mon, 15 Dec 2008 06:12:13 EST news148543933 In an important finding published online in Developmental Cell, researchers at Albert Einstein College of Medicine of Yeshiva University, along with collaborators at Massachusetts Institute of Technology, have identified a protein likely responsible for causing breast cancer to spread. http://phys.org/news147965845.html Medicine & Health Mon, 08 Dec 2008 13:37:25 EST news147965845 A protein that shields tumor cells from cell death and exerts resistance to chemotherapy has an Achilles heel, a vulnerability that can be exploited to target and kill the very tumor cells it usually protects, researchers from the University of Illinois at Chicago show in a new study published in the Dec. 9 issue of Cancer Cell. http://phys.org/news147965138.html Medicine & Health Mon, 08 Dec 2008 13:25:38 EST news147965138 A new Mayo Clinic study found that patients with low-grade gliomas survived longest when they underwent aggressive surgeries to successfully remove the entire tumor. If safely removing the entire tumor was not possible, patients survived significantly longer when surgery was followed by radiation therapy. This study is available online as an advance publication in Neuro-Oncology. http://phys.org/news147546162.html Medicine & Health Wed, 03 Dec 2008 17:02:42 EST news147546162 Cells shut down and stop dividing when their DNA is damaged, in a process known as cellular senescence, so as to prevent damaged DNA from leading to unregulated cell division and therefore cancer. However, a new study, published in this week's issue of PLoS Biology, has found that when these cells shut down they also spew proteins into their surrounding environment. This causes inflammation and sets up conditions that support the development of age-related diseases including, ironically, cancer. The new research includes the first comprehensive molecular description of a paradoxical process that prevents cancer in younger people, but promotes age-related cancers and other maladies later in life. http://phys.org/news147422865.html Biology Tue, 02 Dec 2008 06:47:45 EST news147422865 New data, generated in mice, by Pierre Sonveaux and colleagues, at Université catholique de Louvain, Belgium, have identified a potential new target for anticancer therapeutics. http://phys.org/news146422595.html Medicine & Health Thu, 20 Nov 2008 16:56:35 EST news146422595 A team of researchers at Duke University Medical Center and the Université catholique de Louvain (UCL) has found that lactic acid is an important energy source for tumor cells. In further experiments, they discovered a new way to destroy the most hard-to-kill, dangerous tumor cells by preventing them from delivering lactic acid. http://phys.org/news146421554.html Medicine & Health Thu, 20 Nov 2008 16:39:14 EST news146421554 Over the years, hunting for cancer-related genes and understanding how they work has been an important, although time-consuming, exercise. At Cold Spring Harbor Laboratory (CSHL), five different research groups have now combined their expertise to speed up the rate of discovering cancer-related genes and validating their function in living animals. http://phys.org/news146248350.html Medicine & Health Tue, 18 Nov 2008 16:32:30 EST news146248350 Microvesicles – tiny membrane-covered sacs – released from glioblastoma cells contain molecules that may provide data that can guide treatment of the deadly brain tumor. In their report in the December 2008 Nature Cell Biology, which is receiving early online release, Massachusetts General Hospital (MGH) researchers describe finding tumor-associated RNA and proteins in membrane microvesicles called exosomes in blood samples from glioblastoma patients. Detailed analysis of exosome contents identified factors that could facilitate a tumor's growth through delivery of genetic information or proteins, or signify its vulnerability to particular medications. http://phys.org/news146064135.html Biology Sun, 16 Nov 2008 13:22:15 EST news146064135 In a breakthrough study appearing in advance online publication of Nature Methods, researchers at Albert Einstein College of Medicine of Yeshiva University describe for the first time a method of viewing individual breast cancer cells for several days at a time. The study, by scientists in Einstein's Gruss Lipper Biophotonics Center, provides detail on how cancer cells invade surrounding tissue and reach blood vessels. These movements are the first steps of the potentially deadly stage of cancer known as metastasis. http://phys.org/news145715277.html Medicine & Health Wed, 12 Nov 2008 12:27:57 EST news145715277 Scientists have thought that one way to foil a tumor from generating blood vessels to feed its growth – a process called angiogenesis – was by creating drugs aimed at stopping a key vessel growth-promoting protein. But now the opposite seems to be true. http://phys.org/news145458925.html Medicine & Health Sun, 09 Nov 2008 13:15:25 EST news145458925 Expression of Livin in fresh esophageal cancer tissues was detected by immunohistochemistry (IHC), Western blotting and reverse transcriptase-polymerase chain reaction (RT-PCR), VEGF by Its correlation Western blotting and RT-PCR. Livin positivity was also significantly correlated with tumor stages, increasing with tumor progression. Expression of Livin and VEGF increased with the process of esophageal carcinoma. In the fourth clinical stage, expression of Livin and VEGF was the most significant. Expression of Livin was positive correlation with VEGF. Over-expression of Livin and VEGF contributes to the pathogenesis of esophageal carcinoma. http://phys.org/news144496061.html Medicine & Health Wed, 29 Oct 2008 10:47:41 EST news144496061 Researchers at Cedars-Sinai Medical Center's Maxine Dunitz Neurosurgical Institute who first isolated cancer stem cells in adult brain tumors in 2004 have now identified a molecular mechanism that is involved in the development of these cells from which malignant brain tumors may originate. This could offer a target for scientists seeking treatments that would kill malignant brain tumors at their source and prevent them from recurring. http://phys.org/news144062076.html Medicine & Health Fri, 24 Oct 2008 10:14:36 EST news144062076