http://phys.org/ en-us Phys.org internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. To obtain very-high-resolution 3D images of the cerebral vascular system, a dye is used that fluoresces in the near infrared and can pass through the skin. The Lem-PHEA chromophore, a new product outclassing the best dyes, has been synthesized by a team from the Laboratoire de Chimie. Conducted in collaboration with researchers from the Institut des Neurosciences and the Laboratoire Chimie et Interdisciplinarité: Synthèse, Analyse, Modélisation, this work has been published online in the journal Chemical Science. It opens up significant prospects for better observing the brain and understanding how it works. http://phys.org/news286696414.html Chemistry Thu, 02 May 2013 06:53:40 EST news286696414 (Phys.org)—Scientists may be a step closer to cracking one of the world's most compelling mysteries: the impossible complexity of the brain and its billions of neurons. Cornell researchers have demonstrated a new way of taking high-resolution, three-dimensional images of the brain's inner workings through a three-fold improvement in the depth limits of multiphoton microscopy, a fluorescence-based imaging technique with Cornell roots. http://phys.org/news278058422.html Physics Tue, 22 Jan 2013 06:27:13 EST news278058422 (Phys.org)—Scientists trying to decipher the microenvironment of living biological tissues now have a way of taking high-resolution, high-speed, three-dimensional images of their inner workings. http://phys.org/news275042398.html Physics Tue, 18 Dec 2012 08:40:07 EST news275042398 (Phys.org) -- In the course of its evolution, the architecture of the mouse brain may have barely changed. Similar to the tiny ancestors of modern mammals that lived about 80 million years ago, nerve cells in the mouse visual cortex are densely packed in a small area of ​​the brain. However, during the subsequent evolution of larger brains the architecture of the cerebral cortex was radically restructured. This is the conclusion of an international team of researchers led by scientists at the Max Planck Institute for Dynamics and Self-Organization, the University of Göttingen and the Bernstein Center Göttingen. The brains of larger mammals, such as humans, however, have a completely different structure to those of mice. Processes of self-organisation led to the emergence of modules in which neurons conjointly are responsible for specific tasks. http://phys.org/news256987203.html Biology Wed, 23 May 2012 10:20:13 EST news256987203 In Alzheimer's disease, brain neurons become clogged with tangled proteins. Scientists suspect these tangles arise partly due to malfunctions in a little-known regulatory system within cells. Now, researchers have dramatically increased what they know about this particular regulatory system in mice. Such information will help scientists better understand Alzheimer's and other diseases in humans and could eventually provide new targets for therapies. http://phys.org/news253808670.html Chemistry Mon, 16 Apr 2012 15:25:06 EST news253808670 (PhysOrg.com) -- A team of scientists from the University of Virginia and University of North Carolina in the US have discovered a previously unidentified type of small circular DNA molecule occurring outside the chromosomes in mouse and human cells. The circular DNA is 200-400 base pairs in length and consists of non-repeating sequences. The new type of extra-chromosomal circular DNA (eccDNA) has been dubbed microDNA. Unlike other forms of eccDNA, in microDNA the sequences of base pairs are non-repetitive and are usually found associated with particular genes. This suggests they may be produced by micro-deletions of small sections of the chromosomal DNA. http://phys.org/news250496047.html Biology Fri, 09 Mar 2012 06:14:29 EST news250496047 (PhysOrg.com) -- A team of researchers working at Stanford University have devised a means for building the smallest self-contained fluorescence microscope ever. Weighing just under 2 grams and slightly larger than the end of a pencil, the new microscope is small enough to attach to a mouse head, which means researchers can watch the mouse brain in a natural setting. Led by Mark Schnitzer and Abbas El Gamal, the team describes its findings in Nature Methods. http://phys.org/news235040705.html Physics Mon, 12 Sep 2011 10:05:25 EST news235040705 German scientist Otto H. Warburg's theory on the origin of cancer earned him the Nobel Prize in 1931, but the biochemical basis for his theory remained elusive. http://phys.org/news150954448.html Medicine & Health Mon, 12 Jan 2009 03:47:28 EST news150954448