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Researchers report they have figured out how the cancer-causing bacterium Helicobacter pylori attacks a cell's energy infrastructure, sparking a series of events in the cell that ultimately lead it to self-destruct. http://phys.org/news239365986.html Biology Tue, 01 Nov 2011 11:33:16 EST news239365986 A newly discovered hybrid gene appears to play a direct role in some stomach cancers, according to an international team of scientists led by researchers at Duke-NUS Graduate Medical School Singapore. http://phys.org/news221318805.html Medicine & Health Wed, 06 Apr 2011 14:27:06 EST news221318805 Heavy beer drinkers who have a specific genetic variant in the cluster of three genes that metabolize alcohol are at significantly higher risk of developing non-cardia gastric cancer, according to research presented at the AACR 102nd Annual Meeting 2011, held here April 2-6. http://phys.org/news221134697.html Medicine & Health Mon, 04 Apr 2011 11:18:32 EST news221134697 A research team from South Korea evaluated the difference in diagnostic performance of hydro-stomach computed tomography (CT) to detect early gastric cancer (EGC) between blinded and nonblinded analysis and to assess independent factors affecting visibility of cancer foci. They found that the diagnostic performance of hydrostomach CT to detect an EGC was not significantly different between blinded and nonblinded analysis. The tumor size and invasion depth were independent factors for visibility. http://phys.org/news219402273.html Medicine & Health Tue, 15 Mar 2011 10:05:11 EST news219402273 A research team from China investigated urinary metabolites expression changes among three mice groups using gas chromatography/mass spectrometry. Ten metabolites have differences between the normal group and the cancer group (non-metastasis group and metastasis group). Furthermore, seven metabolites with characteristic expression levels were identified between non-metastasis group and metastasis group. http://phys.org/news218800403.html Medicine & Health Tue, 08 Mar 2011 11:00:01 EST news218800403 A research team from Poland and United Kingdom assessed the absolute number of T-regulatory cells in the peripheral blood of gastric and colorectal cancer patients. The study showed the absolute number of Tregs in the peripheral blood of gastric cancer patients was significantly decreased in comparison to that in the healthy controls. http://phys.org/news215690905.html Medicine & Health Mon, 31 Jan 2011 10:08:48 EST news215690905 A study from researchers in Germany showed that magnetic maneuvering of a modified capsule endoscope in the stomach of healthy volunteers under clinical conditions is safe, well-tolerated, and technically feasible. Maneuverability of the capsule within the stomach was excellent and visualization of the gastric mucosa, the inner lining of the stomach, was satisfactory in the majority of subjects. Apart from a single experiment performed with a supervising flexible gastroscope, this was the first study to use the system in the stomach of healthy subjects. The study appears in the January issue of GIE: Gastrointestinal Endoscopy, the monthly peer-reviewed scientific journal of the American Society for Gastrointestinal Endoscopy (ASGE). http://phys.org/news214573597.html Medicine & Health Tue, 18 Jan 2011 12:10:03 EST news214573597 A research team from Singapore reviewed the outcome of patients with resected gastric cancers treated with capecitabine and radiation compared to 5-fluorouracil with radiation or fluoropyrimidine-based chemotherapy only. They found that survival of patients treated with capecitabine and radiation was comparable to the other two conventional treatments http://phys.org/news204200642.html Medicine & Health Mon, 20 Sep 2010 13:30:01 EST news204200642 An Article published Online First by The Lancet says that for patients with HER2-positive advanced gastric cancer, addition of tastuzumab to standard cisplatinum/fluoropyrimidine chemotherapy results in a median survival of 13.8 months, compared with 11.1 months with chemotherapy alone. This corresponds to a 26% reduction in the death rate for patients in the trastuzumab group. Thus trastuzumab combined with standard chemotherapy could be considered a new standard option for patients with this condition. However, an accompanying Comment questions the cost effectiveness of the treatment. The Article is by Professor Yung-Jue Bang, Seoul National University College of Medicine, Seoul, South Korea, and Dr Eric van Custem, University Hospital Gathuisberg, Leuven, Belgium, and colleagues. http://phys.org/news201461667.html Medicine & Health Thu, 19 Aug 2010 18:34:41 EST news201461667 Although some reports have suggested a link between the use of oral bisphosphonates (drugs that prevent the loss of bone mass) and esophageal cancer, analysis of medical data from more than 80,000 patients in the United Kingdom found that use of these drugs was not significantly associated with new cases of esophageal or gastric cancer, according to a study in the August 11 issue of JAMA. http://phys.org/news200669975.html Medicine & Health Tue, 10 Aug 2010 16:10:04 EST news200669975 Researchers have discovered a mechanism by which Helicobacter pylori, the only known cancer-causing bacterium, disables a tumor suppressor protein in host cells. http://phys.org/news199892547.html Medicine & Health Mon, 02 Aug 2010 06:00:01 EST news199892547 Malnutrition is a common problem in patients with cancer and is associated with a poor outcome. The assessment of nutritional status and its evaluation plays an important role in tailoring nutritional support. A study from South Korea evaluates the relationships between objective and subjective nutritional assessment of gastric cancer patients and suggests that a specific tailored nutritional assessment is needed for accurate measurement of the nutritional status of gastric cancer patients. http://phys.org/news199705508.html Medicine & Health Fri, 30 Jul 2010 12:20:01 EST news199705508 Patients with HER2-positive cancers can have dramatic responses to HER2-targeted drugs but eventually develop resistance to the agents. With that problem in mind, Fox Chase Cancer Center researchers are testing a novel type of antibody called MM-111 in patients with HER2-positive disease who have progressed on standard therapy. http://phys.org/news194876583.html Medicine & Health Fri, 04 Jun 2010 13:40:01 EST news194876583 The bacterium Helicobacter pylori, which lives in the human stomach and is associated with ulcers and gastric cancer, is shaped like a corkscrew, or helix. For years researchers have hypothesized that the bacterium's twisty shape is what enables it to survive - and thrive - within the stomach's acid-drenched environment, but until now they have had no proof. http://phys.org/news194181538.html Medicine & Health Thu, 27 May 2010 12:19:26 EST news194181538 A research team from Japan evaluated the validity of the estimated glomerular filtration rate (eGFR) as a preoperative renal function parameter in patients with gastric cancer. Their study showed that eGFR was as equally reliable as creatinine clearance for assessment of preoperative renal function in patients with gastric cancer. http://phys.org/news193572658.html Medicine & Health Thu, 20 May 2010 11:20:01 EST news193572658 The incidence of a certain type of gastric cancer has declined in the last 30 years for all age groups and races, except for whites 25 to 39 years of age, according to a study in the May 5 issue of JAMA. http://phys.org/news192211103.html Medicine & Health Tue, 04 May 2010 17:50:06 EST news192211103 Patients who have gastric cancer surgery followed by chemotherapy have an associated decreased risk of death and improved disease-free survival compared to patients who have surgery alone, according to an analysis of previous studies, reported in the May 5 issue of JAMA. http://phys.org/news192210809.html Medicine & Health Tue, 04 May 2010 17:30:01 EST news192210809 Important advances in the fight against cancer have come as researchers proved that viruses and cancers interact in ways that were previously unknown to scientists. http://phys.org/news190308154.html Medicine & Health Mon, 12 Apr 2010 17:00:02 EST news190308154 Atrophic gastritis and intestinal metaplasia are two important precursory lesions in the process of intestinal type gastric cancer. However, the precise mechanism of the progression of these two lesions is still unclear, a few studies have investigated the risk of host gene polymorphism on the atrophic gastritis and intestinal metaplasia, but all of them are limited by their one-time point screen. http://phys.org/news190289377.html Medicine & Health Mon, 12 Apr 2010 12:10:01 EST news190289377 Two research units under Singapore's Agency for Science, Technology and Research (A*STAR), the Experimental Therapeutics Centre (ETC) and Singapore Immunology Network (SIgN), are collaborating with Italy's Siena Biotech S.p.A. to develop new drugs and targeted antibodies respectively, which will potentially help millions of cancer and bone loss patients across the world. This is the fifth major collaboration A*STAR has with research centres and universities in Italy. http://phys.org/news189943013.html Medicine & Health Thu, 08 Apr 2010 11:44:27 EST news189943013 A research team in Mexico, led by Dr. Clara Luz Sampieri from the Institute of Public Health of Veracruzana University investigated genetic expression of MMP2 and MMP9 in gastric tumor and gastritis tissues using a population from Mexico. They observed a significantly increased expression of MMP9 in tumor tissues, but not in superficial gastritis. http://phys.org/news189940346.html Medicine & Health Thu, 08 Apr 2010 10:12:46 EST news189940346 In gastric cancer patients who have had part or all of their stomach removed, the hormone ghrelin may lessen post-operative weight loss and improve appetite, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute. http://phys.org/news189257214.html Medicine & Health Wed, 31 Mar 2010 12:27:20 EST news189257214 Helicobacter pylori, a bacterium found in about 50% of humans worldwide, can cause stomach ulcers and, in extreme cases, gastric cancer. In an article for F1000 Medicine Reports, Seiji Shiota and Yoshio Yamaoka discuss the possible eradication of H. pylori infections http://phys.org/news187608287.html Medicine & Health Fri, 12 Mar 2010 10:10:01 EST news187608287 (PhysOrg.com) -- Changes in patients' self-rated quality of life after treatment for esophago-gastric cancer can predict the chances for long-term survival. This is the result researchers at the Swedish medical university Karolinska Institutet made, in a new study published in the Journal of Clinical Oncology. http://phys.org/news187383793.html Medicine & Health Tue, 09 Mar 2010 19:30:06 EST news187383793 A combination of two targeted therapies already shown to be effective in breast cancer packs an effective one-two punch against a subset of gastric cancers that have a specific genetic mutation, a study at UCLA's Jonsson Comprehensive Cancer Center has found. http://phys.org/news186829559.html Medicine & Health Wed, 03 Mar 2010 09:06:11 EST news186829559 Mechanisms of gastric carcinogenesis are still not yet understood. Studies have linked genetic and epigenetic factors or microbiological agents to gastric cancer, but they didn't look for these events together. Dr. Ferrasi from Brazil verified the methylation profile, microsatellite instability (MSI), Helicobacter pylori status and Epstein Barr virus infection in gastric cancer samples. Intestinal and diffuse adenocarcinoma showed different methylation profiles and an association was found between methylation and Helicobacter pylori-cagA+. http://phys.org/news184963044.html Medicine & Health Wed, 10 Feb 2010 01:10:02 EST news184963044 Helicobacter pylori (H. pylori) colonize the human stomach and present genetic mechanisms to evade the host immune response allowing their persistence in this habitat for years. A study involving 130 H. pylori strains isolated from patients living in different Chilean cities revealed that, nearly half of them carry the hopE and hopV genes. The results suggest that these genes can be turned on and off, and are likely to be involved in avoiding immune recognition. http://phys.org/news184959168.html Medicine & Health Tue, 09 Feb 2010 23:10:01 EST news184959168 The classification of intestinal metapasia (IM) is confusing. A research group in China observed IM in gastric biopsies and divided IM into simple IM (SIM) and atypical IM (AIM). By detecting three tumor-associated proteins, p53, c-erbB-2 and Ki67, in IM and gastric cancer, they compared two types of classification in intestinal metaplasia. They found that AIM may have a much more close relationship with gastric cancer. http://phys.org/news184959105.html Medicine & Health Tue, 09 Feb 2010 20:40:01 EST news184959105 Two percent to fifteen percent of patients with gastric cancer (GC) are younger than 45 years of age and there has been an increase in the relative proportion of young age GC compared with older age GC, especially in young females. The question of whether young age GC is different from that of older patients has been raised but remains unresolved. http://phys.org/news183117685.html Medicine & Health Tue, 19 Jan 2010 10:01:37 EST news183117685 Researchers report that Helicobacter pylori, the only bacterium known to survive in the harsh environment of the human stomach, directly activates an enzyme in host cells that has been associated with several types of cancer, including gastric cancer. http://phys.org/news182001373.html Medicine & Health Wed, 06 Jan 2010 11:56:47 EST news182001373