http://phys.org/ en-us Phys.org provides the latest news from Wellcome Trust Sanger Institute (Phys.org)—For the first time, researchers sequenced DNA molecules without the need for the standard pre-sequencing workflow known as library preparation. http://phys.org/news274444936.html Biology Tue, 11 Dec 2012 10:42:37 EST news274444936 DNA sequencing of 36 complete Y chromosomes has uncovered a previously unknown period when the human population expanded rapidly. This population explosion occurred 40 to 50 thousand years ago, between the first expansion of modern humans out of Africa 60 to 70 thousand years ago and the Neolithic expansions of people in several parts of the world starting 10 thousand years ago. http://phys.org/news270810711.html Biology Tue, 30 Oct 2012 10:12:56 EST news270810711 Researchers show for the first time that a mammal begins to suckle its mother's milk through a learned response built on learning her unique combination of smells. When it is born, the newborn is exposed to the smell of its mother's amniotic fluid and the baby then responds to those smells to feed. http://phys.org/news268570636.html Biology Thu, 04 Oct 2012 12:00:02 EST news268570636 Researchers have found the subtle genetic differences that make one parasite far more virulent than its close relative. http://phys.org/news251653819.html Biology Thu, 22 Mar 2012 17:00:01 EST news251653819 In a study released today in Nature Genetics, researchers have found that Chlamydia has evolved more actively than was previously thought. Using whole genome sequencing the researchers show that the exchange of DNA between different strains of Chlamydia to form new strains is much more common than expected. http://phys.org/news250690363.html Biology Sun, 11 Mar 2012 14:00:09 EST news250690363 The assembly of the gorilla genome was announced today, March 7, by a multi-national group of researchers. The gorilla is the last genus of the living great apes to have its genome decoded. While confirming that our closest relative is the chimpanzee, the team showed that much of the human genome more closely resembles the gorilla than it does the chimpanzee genome. http://phys.org/news250346642.html Biology Wed, 07 Mar 2012 13:00:04 EST news250346642 Two remarkable discoveries were today revealed by researchers into genome analysis of Leishmania parasites. These results uncovered a surprising level of variation at the genome structure level. http://phys.org/news238954669.html Biology Thu, 27 Oct 2011 17:18:24 EST news238954669 Researchers from the Wellcome Trust Sanger Institute have today announced a new technique to reprogramme human cells, such as skin cells, into stem cells. Their process increases the efficiency of cell reprogramming by one hundred-fold and generates cells of a higher quality at a faster rate. http://phys.org/news237465562.html Biology Mon, 10 Oct 2011 15:00:01 EST news237465562 Researchers have developed a valuable mouse genetic blueprint that will accelerate future research and understanding of human genetics. The international team, led by researchers at the Wellcome Trust Sanger Institute and the University of Oxford, explains in two papers published in Nature on 14 September 2011 how they decoded and compared the genome sequence of 17 mouse strains. http://phys.org/news235217841.html Biology Wed, 14 Sep 2011 13:00:01 EST news235217841 Researchers have probed deeper into human evolution by developing an elegant new technique to analyse whole genomes from different populations. One key finding from the Wellcome Trust Sanger Institute's study is that African and non-African populations continued to exchange genetic material well after migration out-of-Africa 60,000 years ago. This shows that interbreeding between these groups continued long after the original exodus. http://phys.org/news229780842.html Biology Wed, 13 Jul 2011 13:01:46 EST news229780842 An international consortium of researchers report today in Nature that they have knocked out almost 40 per cent of the genes in the mouse genome. The completed resource will power studies of gene activity in models of human disease. http://phys.org/news227361365.html Biology Wed, 15 Jun 2011 13:00:05 EST news227361365 Researchers have described how the most common gene mutation found in acute myeloid leukaemia starts the process of cancer development and how it can cooperate with a well-defined group of other mutations to cause full-blown leukaemia. http://phys.org/news220449667.html Medicine & Health Sun, 27 Mar 2011 13:02:02 EST news220449667 A new UK nationwide project aimed at improving the care and diagnosis of developmental disorders and understanding their relation to the human genome is announced today. The Deciphering Developmental Disorders (DDD) Project aims to improve the diagnosis and care of children in the UK who fail to develop normally due to changes in their genetic makeup. Its goal is to collect comprehensive genomic data and from this develop clinical tools to unlock the genetic reasons for the developmental problems in these children. http://phys.org/news219990007.html Medicine & Health Tue, 22 Mar 2011 05:20:30 EST news219990007 Researchers have provided new clues into the genetics underlying a chronic form of liver disease, called primary biliary cirrhosis, which can lead to transplant surgery for patients. The new study identifies 15 genetic regions that affect a person's risk of developing the disease, more than trebling the number of known genetic regions, which now stands at 22. http://phys.org/news219243571.html Medicine & Health Sun, 13 Mar 2011 14:00:06 EST news219243571 New research provides the first detailed genetic picture of an evolutionary war between Streptococcus pneumoniae bacteria and the vaccines and antibiotics used against it over recent decades. Large-scale genome sequencing reveals patterns of adaptation and the spread of a drug-resistant lineage of the S. pneumoniae bacteria. http://phys.org/news215360205.html Biology Thu, 27 Jan 2011 14:17:22 EST news215360205