The Scripps Research Institute (TSRI) is a biomedical research corporation established in La Jolla, California with another site in Jupiter, Florida. Its origins stem from a large endowment from Ellen Browning Scripps in the 1920s originally targeted for research on immune disorders. In the 1990s the combined Scripps Clinic and Research Institute became separate entitities. Today, TSRI is one of the most prolific and active research institutes in the United States with a wide range of human disorders/conditions in its focus. Namely, cancer biology, cell therapy, genetics, molecular and experimental medicine, neurobiology and more. The newly constructed Scripps Florida focuses on drug discoveries, basic biomedical research and technologies.
End of the dinosaurs gave rise to the modern 'Age of Fishes,' researchers find
A pair of paleobiologists from Scripps Institution of Oceanography, UC San Diego have determined that the world's most numerous and diverse vertebrates – ray-finned fishes – began their ecological dominance ...
Team gets new close-up view of key part of Ebola virus life cycle
A new study led by scientists at The Scripps Research Institute (TSRI) reveals a key part of the Ebola virus life cycle at a higher resolution than ever before. The research sheds light on how Ebola virus ...
Study leads to 3-D structures of key molecule implicated in diseases of the brain
Scientists at The Scripps Research Institute (TSRI) have teamed up with several other institutions and pharmaceutical companies, including the University of Southern California (USC), San Diego's Receptos ...
Study points to unexplored realm of protein biology, drug targets
Scientists at The Scripps Research Institute (TSRI) have devised a powerful set of chemical methods for exploring the biology of proteins.
Chemists find efficient, scalable way to synthesize potential brain-protecting compound
Chemists at The Scripps Research Institute (TSRI) have invented the first practical, scalable method for synthesizing jiadifenolide, a plant-derived molecule that may have powerful brain-protecting properties.
Hormone 'erases' male smell for female mice
Everyone knows that a plate of food doesn't look as delicious after you've already eaten a big meal. But imagine if your internal state actually made you blind to food.
Modern alchemy: Chemists devise synthesis of valuable exotic compounds
Chemists at The Scripps Research Institute (TSRI) have discovered a broad and strikingly inexpensive method for synthesizing "amines," a class of organic compounds prominent in drugs and other modern products.
Researchers investigate an enzyme important for nervous system health
Scientists from The Scripps Research Institute (TSRI), working closely with researchers at the National Institutes of Health (NIH), have mapped out the structure of an important protein involved in cellular ...
Scientists reveal unique mechanism of natural product with powerful antimicrobial action
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have uncovered the unique mechanism of a powerful natural product with wide-ranging antifungal, antibacterial, anti-malaria and ...
Scientists confirm key targets of new anti-cancer drug candidates
Ribosomes, ancient molecular machines that produce proteins in cells, are required for cell growth in all organisms, accomplishing strikingly complex tasks with apparent ease. But defects in the assembly process and its regulation ...
Scientists show proteins critical in day-night cycles also protect cells from mutations
A good night's sleep does more than prevent yawning. New research from The Scripps Research Institute (TSRI) shows that two proteins critical for maintaining healthy day-night cycles also protect against ...
Scientists reveal structural secrets of nature's little locomotive
A team led by scientists at The Scripps Research Institute (TSRI) has determined the basic structural organization of a molecular motor that hauls cargoes and performs other critical functions within cells.
Go meta: New technique expands possibilities for molecular designers
Chemists at The Scripps Research Institute (TSRI) have developed a broadly useful technique for building new drug molecules and other chemical products.
Scientists find clues to cancer drug failure
Cancer patients fear the possibility that one day their cells might start rendering many different chemotherapy regimens ineffective. This phenomenon, called multidrug resistance, leads to tumors that defy ...
New study shows safer methods for stem cell culturing
A new study led by researchers at The Scripps Research Institute (TSRI) and the University of California (UC), San Diego School of Medicine shows that certain stem cell culture methods are associated with increased DNA mutations. ...