The Scripps Research Institute (TSRI) is a biomedical research corporation established in La Jolla, California with another site in Jupiter, Florida. Its origins stem from a large endowment from Ellen Browning Scripps in the 1920s originally targeted for research on immune disorders. In the 1990s the combined Scripps Clinic and Research Institute became separate entitities. Today, TSRI is one of the most prolific and active research institutes in the United States with a wide range of human disorders/conditions in its focus. Namely, cancer biology, cell therapy, genetics, molecular and experimental medicine, neurobiology and more. The newly constructed Scripps Florida focuses on drug discoveries, basic biomedical research and technologies.
Researchers capture picture of microRNA in action
Biologists at The Scripps Research Institute (TSRI) have described the atomic-level workings of "microRNA" molecules, which control the expression of genes in all animals and plants.
Scientists make enzyme that could help explain origins of life
Mimicking natural evolution in a test tube, scientists at The Scripps Research Institute (TSRI) have devised an enzyme with a unique property that might have been crucial to the origin of life on Earth.
Chemists achieve new technique with profound implications for drug development
Breaking carbon-hydrogen (C-H) bonds to alter existing molecules to create new ones is an increasingly important avenue for drug development. Of particular interest is mirror-image or "one-handed" compounds, ...
New studies bring scientists closer to combating dangerous unstable proteins
Scientists at The Scripps Research Institute (TSRI) have discovered a way to decrease deadly protein deposits in the heart, kidney and other organs associated with a group of human diseases called the systemic amyloid diseases.
Ancient protein-making enzyme moonlights as DNA protector
Scientists at The Scripps Research Institute (TSRI) have found that an enzyme best known for its fundamental role in building proteins has a second major function: to protect DNA during times of cellular ...
Chemists modify antibiotic to vanquish resistant bacteria
Scientists at The Scripps Research Institute (TSRI) have devised a new antibiotic based on vancomycin that is powerfully effective against vancomycin-resistant strains of MRSA and other disease-causing bacteria.
Scientists make diseased cells synthesize their own drug
In a new study that could ultimately lead to many new medicines, scientists from the Florida campus of The Scripps Research Institute (TSRI) have adapted a chemical approach to turn diseased cells into unique manufacturing ...
Mystery solved: 'Sailing stones' of death valley seen in action for the first time
(Phys.org) —Racetrack Playa is home to an enduring Death Valley mystery. Littered across the surface of this dry lake, also called a "playa," are hundreds of rocks – some weighing as much as 320 kilograms ...
Chemists uncover powerful new click chemistry reactivity
Chemists led by Nobel laureate K. Barry Sharpless at The Scripps Research Institute (TSRI) have used his click chemistry to uncover unprecedented, powerful reactivity for making new drugs, diagnostics, plastics, smart materials ...
Scientists generate long-sought molecular map of critical genetic machinery
A team led by researchers at The Scripps Research Institute (TSRI) has used advanced electron microscopy techniques to determine the first accurate structural map of Mediator, one of the largest and most ...
Chemists discover structure of cancer drug candidate
Chemists at The Scripps Research Institute (TSRI) have determined the correct structure of a highly promising anticancer compound approved by the U.S. Food and Drug Administration (FDA) for clinical trials ...
Scientists create first living organism that transmits added letters in DNA 'alphabet'
Scientists at The Scripps Research Institute (TSRI) have engineered a bacterium whose genetic material includes an added pair of DNA "letters," or bases, not found in nature. The cells of this unique bacterium ...
Scientists reveal molecular secrets behind resveratrol's health benefits
Resveratrol has been much in the news as the component of grapes and red wine associated with reducing "bad cholesterol," heart disease and some types of cancer. Also found in blueberries, cranberries, mulberries, ...
To mark territory or not to mark territory: Breaking the pheromone code
A team led by scientists at The Scripps Research Institute (TSRI) has deciphered the surprisingly versatile code by which chemical cues help trigger some of the most basic behaviors in mice.
Team solves decades-old mystery of how cells keep from bursting
A team led by scientists at The Scripps Research Institute (TSRI) has identified a long-sought protein that facilitates one of the most basic functions of cells: regulating their volume to keep from swelling excessively.