The Scripps Research Institute (TSRI) is a biomedical research corporation established in La Jolla, California with another site in Jupiter, Florida. Its origins stem from a large endowment from Ellen Browning Scripps in the 1920s originally targeted for research on immune disorders. In the 1990s the combined Scripps Clinic and Research Institute became separate entitities. Today, TSRI is one of the most prolific and active research institutes in the United States with a wide range of human disorders/conditions in its focus. Namely, cancer biology, cell therapy, genetics, molecular and experimental medicine, neurobiology and more. The newly constructed Scripps Florida focuses on drug discoveries, basic biomedical research and technologies.
New TSRI metabolomic platform reveals fundamental flaw in common lab technology
A new study led by scientists at The Scripps Research Institute (TSRI) shows that a technology used in thousands of laboratories, called gas chromatography mass spectrometry (GC-MS), fundamentally alters the samples it analyzes.
Modern alchemy: Chemists devise synthesis of valuable exotic compounds
Chemists at The Scripps Research Institute (TSRI) have discovered a broad and strikingly inexpensive method for synthesizing "amines," a class of organic compounds prominent in drugs and other modern products.
End of the dinosaurs gave rise to the modern 'Age of Fishes,' researchers find
A pair of paleobiologists from Scripps Institution of Oceanography, UC San Diego have determined that the world's most numerous and diverse vertebrates – ray-finned fishes – began their ecological dominance of the oceans ...
Structural discoveries could aid in better drug design
F. Scott Fitzgerald once said that the test of a first-rate intelligence is the ability to hold two opposed ideas in mind at the same time and still retain the ability to function. Now, scientists from the Florida campus ...
Scientists uncover surprising mechanism behind antibiotic-resistant bacteria
Every year, more strains of bacteria develop resistance to the antibiotics we use to treat deadly infections. At The Scripps Research Institute (TSRI) scientists have been working to develop new forms of these drugs, including ...
Team discovers the ancient origins of deadly Lassa virus
Working as part of an international team in the United States and West Africa, a researcher at The Scripps Research Institute (TSRI) has published new findings showing the ancient roots of the deadly Lassa virus, a relative ...
Chemists report nicotine-chomping bacteria may hold key to anti-smoking therapy
A new study from scientists at The Scripps Research Institute (TSRI) explores a bacterial enzyme that might be used as a drug candidate to help people quit smoking. The research shows that this enzyme can be recreated in ...
Hormone 'erases' male smell for female mice
Everyone knows that a plate of food doesn't look as delicious after you've already eaten a big meal. But imagine if your internal state actually made you blind to food.
Chemists find efficient, scalable way to synthesize potential brain-protecting compound
Chemists at The Scripps Research Institute (TSRI) have invented the first practical, scalable method for synthesizing jiadifenolide, a plant-derived molecule that may have powerful brain-protecting properties.
Scientists determine how antibiotic gains cancer-killing sulfur atoms
In a discovery with implications for future drug design, scientists from the Florida campus of The Scripps Research Institute (TSRI) have shown an unprecedented mechanism for how a natural antibiotic with antitumor properties ...