The Scripps Research Institute (TSRI) is a biomedical research corporation established in La Jolla, California with another site in Jupiter, Florida. Its origins stem from a large endowment from Ellen Browning Scripps in the 1920s originally targeted for research on immune disorders. In the 1990s the combined Scripps Clinic and Research Institute became separate entitities. Today, TSRI is one of the most prolific and active research institutes in the United States with a wide range of human disorders/conditions in its focus. Namely, cancer biology, cell therapy, genetics, molecular and experimental medicine, neurobiology and more. The newly constructed Scripps Florida focuses on drug discoveries, basic biomedical research and technologies.
Scientists develop powerful new method for finding therapeutic antibodies
Scientists at The Scripps Research Institute (TSRI) have devised a powerful new technique for finding antibodies that have a desired biological effect. Antibodies, which can bind to billions of distinct targets, ...
May 23, 2013
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Team finds key to gene-silencing activity, opens door to new class of therapies
A team led by scientists at The Scripps Research Institute (TSRI) has found how to boost or inhibit a gene-silencing mechanism that normally serves as a major controller of cells' activities. The discovery ...
May 09, 2013
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Team discovers how a protein finds its way
(Phys.org) —Proteins, the workhorses of the body, can have more than one function, but they often need to be very specific in their action or they create cellular havoc, possibly leading to disease.
Apr 29, 2013
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Scripps vessel named for Sally Ride
U.S. Secretary of the Navy Ray Mabus announced the nation's newest research vessel will be named R/V Sally Ride, in honor of the former UC San Diego faculty member who was the first American female astronaut and the youngest ...
Apr 17, 2013
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Chemists illuminate elusive mechanism of widely used click reaction
Scientists at The Scripps Research Institute (TSRI) have illuminated the mechanism at the heart of one of the most useful processes in modern chemistry. A reaction that is robust and easy to perform, it is widely employed ...
Apr 04, 2013
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Compounds found that alter cell signaling, could lead to new breast cancer treatments
Using a broad spectrum of analytical tools, scientists from the Florida campus of The Scripps Research Institute (TSRI) have uncovered a class of novel compounds that can alter cell signaling activity, resulting in a variety ...
Mar 26, 2013
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Scientists discover structure of protein essential for quality control, nerve function
(Phys.org)—Using an innovative approach, scientists at The Scripps Research Institute (TSRI) have determined the structure of Ltn1, a recently discovered "quality-control" protein that is found in the cells ...
Jan 14, 2013
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Chemists devise inexpensive, benchtop method for marking and selecting cells
Chemists at The Scripps Research Institute (TSRI) have found an easier way to perform one of the most fundamental tasks in molecular biology. Their new method allows scientists to add a marker to certain cells, so that these ...
Jan 08, 2013
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New study defines the long-sought structure of a protein necessary for cell-cell interaction
Scientists know that cells in all higher organisms cells need to bind to each other for the development, architecture, maintenance and function of tissues. Mysteries have remained, however, about exactly ...
Jan 06, 2013
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A feat in synthetic chemistry: Steroids that only nature could make on a large scale
Scientists at The Scripps Research Institute (TSRI) have achieved a feat in synthetic chemistry by inventing a scalable method to make complex natural compounds known as "polyhydroxylated steroids." These ...
Jan 03, 2013
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Chinese medicine yields secrets: Atomic mechanism of 2-headed molecule derived from Chang Shan shown
The mysterious inner workings of Chang Shan—a Chinese herbal medicine used for thousands of years to treat fevers associated with malaria—have been uncovered thanks to a high-resolution structure solved ...
Dec 23, 2012
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Scientists create new approach to destroy disease-associated RNAs in cells
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have developed a new approach to alter the function of RNA in living cells by designing molecules that recognize and disable RNA targets. As a proof ...
Dec 20, 2012
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Scientists develop new compound that reverses fatty liver disease
(Phys.org)—Scientists from the Florida campus of The Scripps Research Institute (TSRI) have developed the first synthetic compound that can reverse the effects of a serious metabolic condition known as fatty liver disease. ...
Dec 19, 2012
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Scientists discover how two proteins help keep cells healthy
Scientists at The Scripps Research Institute (TSRI) have determined how two proteins help create organelles, or specialized subunits within a cell, that play a vital role in maintaining cell health. This discovery opens the ...
Dec 02, 2012
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New powerful toolkit accelerates creation of potential new drugs
Scientists at The Scripps Research Institute (TSRI) have invented a set of chemical tools that is radically simplifying the creation of potential new drug compounds.
Nov 28, 2012
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