Rockefeller University

Matrix fragments trigger fatal excitement

Shredded extracellular matrix (ECM) is toxic to neurons. Chen et al. reveal a new mechanism for how ECM demolition causes brain damage. The study will appear in the December 29, 2008 issue of The Journal of Cell Biology.

dateDec 29, 2008 in
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FHL1 helps build muscle mass

Cowling et al. report how to build muscle mass with FHL1. The protein partners with and activates the transcription factor, NFATc1. Encouraging this partnership might provide a possible treatment for muscle wasting disorders. ...

dateDec 15, 2008 in
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What makes an axon an axon?

Inside every axon is a dendrite waiting to get out. Hedstrom et al. converted mature axons into dendrites by banishing a protein crucial for neuron development. The results suggest that this transformation could occur after ...

dateNov 10, 2008 in
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Molecule stops DNA replication in its tracks

(PhysOrg.com) -- When a dividing cell duplicates its genetic material, a molecular machine called a sliding clamp travels along the DNA double helix, tethering the proteins that perform the replication. Researchers from the ...

dateOct 20, 2008 in
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Newly identified cells make fat

To understand where fat comes from, you have to start with a skinny mouse. By using such a creature, and observing the growth of fat after injections of different kinds of immature cells, scientists at the Howard Hughes Medical ...

dateOct 04, 2008 in
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