Rockefeller University

Fibroblasts invade at a snail's pace

A transcription factor known to drive the formation of fibroblasts during development also promotes their ability to invade and remodel surrounding tissues, report Rowe et al. in the February 9, 2009 issue ...

Feb 02, 2009 5 / 5 (1) 0

'Birth control' for centrioles

Like DNA, centrioles need to duplicate only once per cell cycle. Rogers et al. uncover a long-sought mechanism that limits centriole copying, showing that it depends on the timely demolition of a protein that ...

Jan 26, 2009 4 / 5 (2) 0

Lamin B locks up Oct-1

A large fraction of the transcription factor Oct-1 is associated with the inner nuclear envelope, but how and why it is retained there was unknown.

Jan 12, 2009 not rated yet 0

Lamin A/C deficiency is 'unnerving'

Mutations in the nuclear intermediate filament lamin A/C (LMNA) gene are associated with Emery-Dreifuss muscular dystrophy, but cause the disease by unknown mechanisms. Méjat et al. show that one mechanism ...

Jan 05, 2009 3 / 5 (1) 0

Matrix fragments trigger fatal excitement

Shredded extracellular matrix (ECM) is toxic to neurons. Chen et al. reveal a new mechanism for how ECM demolition causes brain damage. The study will appear in the December 29, 2008 issue of The Journal of ...

Dec 29, 2008 5 / 5 (4) 0