High-resolution mapping method for G4 DNA structures developed

While investigating the unusual G quadruplex DNA structure (G4), the Simon Elsässer group has developed a more accurate method for mapping these structures in the genome. G4 CUT&Tag revealed numerous G4s in the human and ...

New group of antibacterial molecules identified

Researchers at Karolinska Institutet, Umeå University, and the University of Bonn have identified a new group of molecules that have an antibacterial effect against many antibiotic-resistant bacteria. Since the properties ...

Increased use of digital tools in post-pandemic teaching

The experience of the rapid transition to distance learning during the pandemic has been evaluated in a new report. Here are opinions from both teachers and students which will now be used to further develop teaching methods.

Frizzleds are dynamic, molecular machines

Maria Kowalski-Jahn and Hannes Schihada, two postdocs in the Schulte laboratory, have used a novel technology of fluorescently labeling receptors with a minimally invasive technique and detecting structural rearrangements ...

New biomarker for severe COVID-19

During the pandemic, it has become evident that people with cardiovascular disease and obesity are at much higher risk of developing very severe, even fatal COVID-19 disease. Researchers at Karolinska Institutet have identified ...

Artificial intelligence takes structural biology to the next level

A scientist at Karolinska Institutet reports that machine learning can be used to gain insights into molecular events that change the shape of proteins after they are made, regulating their ability to interact with each other. ...

Autophagy in major human diseases

In a consensus article, Federico Pietrocola, at the Department of Biosciences and Nutrition, KI, and colleagues explore the pathophysiological relevance of autophagy in human illnesses, while highlighting the therapeutic ...

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