Mutant stem cells defy rules of development

Imagine you're baking a cake, but you run out of salt. Even with the missing ingredient, the batter still looks like cake batter, so you stick it in the oven and cross your fingers, expecting to end up with something pretty ...

Researchers pioneer new method to edit genes in human cells

Over the past decade, the CRISPR genome-editing system has revolutionized molecular biology, giving scientists the ability to alter genes inside living cells for research or medical applications. Now, researchers at Gladstone ...

How do developing spinal cords choose 'heads' or 'tails'?

The progression from a round ball of cells to an embryo with a head and a tail is one of the most critical steps in an organism's development. But just how cells first start organizing themselves with directionality along ...

Teaching a computer program to track cells

Following the minuscule movements of every cell in a petri dish would be a painstaking task for any human. But teach a set of computer programs to do the job, and they can complete it quickly and even observe things that ...

Recreating the earliest stages of life

In their effort to understand the very earliest stages of life and how they can go wrong, scientists are confronted with ethical issues surrounding the use of human embryos. The use of animal embryos is also subject to restrictions ...

XYZeq: A better map of cell diversity

Not all cancer cells within a tumor are created equal; nor do all immune cells (or all liver or brain cells) in your body have the same job. Much of their function depends on their location. Now, researchers at Gladstone ...

A genetic shortcut to help visualize proteins at work

One of biologists' most vexing tasks is figuring out how proteins, the molecules that carry the brunt of a cell's work, do their job. Each protein has a variety of knobs, folds, and clefts on its surface that dictate what ...

Cellular energy audit reveals energy producers and consumers

Adenosine triphosphate, or ATP, is the cellular energy currency that is as valuable to the human body as the dollar is to the US economy. Too high or too low levels of ATP in some cell types have been linked to a variety ...

Herpesvirsuses hedge their bets to optimize survival

When investors hedge a bet, they divvy their money between risky investments, which might make a large profit, and safe investments, which help ensure that not everything is lost in a market crash. The herpesvirus cytomegalovirus, ...

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