Research team spins the Sleeping Beauty transposase

EMBL scientists have developed a new variant of the so-called Sleeping Beauty transposase. It has dramatically improved biochemical features, including enhanced stability and intrinsic cell penetrating properties. This transposase ...

MEG3 kissing loops essential for tumor suppression

A team of researchers in the Marcia group at EMBL Grenoble have discovered that the tumor suppressor MEG3 adopts a complex three-dimensional structure to fulfill its function. Furthermore, they were able to fine-tune its ...

Pinpointing the molecular mechanisms of ageing

Although each and every one of us goes through it, ageing is a poorly understood process. Researchers have used a biomarker called the epigenetic clock to identify a gene that is closely linked to ageing in humans. The study, ...

Does rearranging chromosomes affect their function?

Molecular biologists have long thought that domains in the genome's 3-D organization control how genes are expressed. After studying highly rearranged chromosomes in fruit flies, EMBL researchers now reveal that while this ...

Snapshots of the flu virus replication machine in action

Researchers from EMBL Grenoble have, for the first time, observed different functional states of the influenza virus polymerase as it is actively transcribing. These results, published in Nature Structural & Molecular Biology, ...

Sex and diet affect protein machineries

Scientists from EMBL Heidelberg have discovered that the collection of proteins in an animal cell—called the proteome—is substantially affected by both the animal's sex and its diet. Understanding these individual proteomes ...

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