Re-trafficking proteins to fight Salmonella infections

When humans get infected by pathogenic bacteria, the body's immune system tries to eliminate the intruders. One way of doing this is by launching an inflammatory response—a cascade of events that includes the expression ...

Enabling functional genomics studies in individual cells

Although the first complete sequence of the human genome was reported more than 15 years ago, the biological functions of large parts of the genome are not yet known. Scientists working in the field of functional genomics ...

DNA damage and faulty repair jointly cause mutations

Researchers at EMBL's European Bioinformatics Institute (EMBL-EBI), the University of Dundee and the Wellcome Sanger Institute analysed over 2700 genomes from C. elegans worms in order to better understand the causes of mutations. ...

Unprecedented single-cell studies in virtual embryo

"How are the many different cell types in the body generated during embryonic development from an egg, which is only a single cell? This is one of the most fundamental questions in biology," explains Dr. Pierre Neveu, group ...

Monitoring organs and cells in living fly larvae

Small changes in a cell's composition can radically transform its function and drive the development of diseases like diabetes, cancer or neuronal dysfunction. Scientists led by the European Molecular Biology Laboratory in ...

Scientists explore how females shut off their second X chromosome

Researchers at the European Molecular Biology Laboratory (EMBL) in Heidelberg and Institut Curie in Paris have shown that the protein SPEN plays a crucial role in the process of X-chromosome inactivation, whereby female mammalian ...

Analysis of human genomes in the cloud

Most bioinformatics software used for genomic analysis is experimental in nature and has a relatively high failure rate. In addition, cloud infrastructure itself, when run at scale, is prone to system crashes. These setbacks ...

Melting reveals drug targets in a living organism

Developing new medicines and understanding how they target specific organs often gives a crucial advantage in the fight against human diseases. An international team led by researchers at the European Molecular Biology Laboratory ...

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