The world's first DNA 'tricorder' in your pocket

Cold Spring Harbor Laboratory (CSHL) scientists developed the world's first mobile genome sequence analyzer, a new iPhone app called iGenomics. By pairing an iPhone with a handheld DNA sequencer, users can create a mobile ...

Birds of a feather do flock together

Nearly 200 years ago, Charles Darwin noted striking diversity among the finches of the Galapagos Islands, and his observations helped him propose the role of natural selection in shaping species. Today, some biologists focus ...

ENCODE3: Interpreting the human and mouse genomes

Scientists around the world have access to a rich trove of information through the Encyclopedia of DNA Elements (ENCODE)—annotated versions of the human and mouse genomes that are vital for interpreting their genetic codes. ...

Brain receptor pulls open electrical gate like a puppet master

For the first time, researchers in the lab of CSHL Professor Hiro Furukawa have been able to track each atom in the NMDA receptor, an important brain protein, as it transmits or inhibits neural signals. Critical for brain ...

How to tune out common odors and focus on important ones

Quantitative biologists at CSHL have figured out how a fly brain learns to ignore overwhelmingly prevalent, mundane odors to focus on more important ones. It's an important step towards understanding how our senses work and ...

Predicting the evolution of genetic mutations

Quantitative biologists David McCandlish and Juannan Zhou at Cold Spring Harbor Laboratory have developed an algorithm with predictive power, giving scientists the ability to see how specific genetic mutations can combine ...

Images of 'invisible' holes on cells may jumpstart research

High blood pressure, inflammation, and the sensation of pain may rely in part on tiny holes on the surface of cells, called pores. Living cells react to the environment, often by allowing water and other molecules to pass ...

New look at odd holes involved in taste, Alzheimer's, asthma

Many cells are covered with mysterious large holes, pores that have been associated with the sense of taste as well as Alzheimer's disease, depression, and even asthma. Knowing the structure of these varied holes will help ...

Finally, machine learning interprets gene regulation clearly

In this age of "big data," artificial intelligence (AI) has become a valuable ally for scientists. Machine learning algorithms, for instance, are helping biologists make sense of the dizzying number of molecular signals that ...

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