Cincinnati Children's Hospital Medical Center (CCHMC) was founded in 1833 in Cincinnati, Ohio. The hospital medical center is affiliated with the University of Cincinnati. Noteworthy, among CCHMC achievements include, an award for exemplary research in Pediatric care from the National Institutes of Health, consistent funding by the NIH, and is one of the five training centers for pediatric care in the USA.
Study suggests antioxidant treatment may help NF1-linked behavioral issues
New research in mouse models suggests that treatment with antioxidants may help reduce behavioral issues linked to the genetic nervous system disorder Neurofibromatosis 1 (NF1) and an associated condition called Costello ...
Fruit flies reveal surprising new evolutionary link for studying human health
New research reveals that fruit flies and mammals may share a surprising evolutionary link in how they control body temperature through circadian rhythm, unlocking new ways to study the insects as models of ...
New candidate drug stops cancer cells, regenerates nerve cells
Scientists have developed a small-molecule-inhibiting drug that in early laboratory cell tests stopped breast cancer cells from spreading and also promoted the growth of early nerve cells called neurites.
Researchers identify biomarkers of poor outcomes in preemies
Researchers at Cincinnati Children's Hospital Medical Center have identified biomarkers of poor outcomes in preterm infants that may help identify new approaches to prevention.
Fruit fly study digs deeper into poorly understood details of forming embryos
Using fruit flies as a model to study embryo formation, scientists report in Nature Cell Biology that molecular breakdown of a protein called Bicoid is vital to normal head-to-tail patterning of the insect's offspring.
Stem cells turned into complex, functioning intestinal tissue in lab
For the first time, scientists have created functioning human intestinal tissue in the laboratory from pluripotent stem cells.
Novel regulatory process for T cells may help explain immune system diseases
A newly identified regulatory process affecting the biology of immune system T cells should give scientists new approaches to explore the causes of autoimmunity and immune deficiency diseases.
Inhibiting cell signaling pathway may improve bone marrow transplant success rate
Identification of a molecular communications pathway that influences the mobilization of hematopoietic (blood) stem cells could lead to targeted therapies for improving bone marrow transplant success rates.
Study points to key genetic driver of severe allergic asthma
Scientists have identified a genetic basis for determining the severity of allergic asthma in experimental models of the disease.
Viral infection predicts heart transplant loss in children
Scientists report that viral infection of the heart is a predictor of heart transplant failure in young children and adolescents, although it can be detected by screening for viral genes and treated to improve organ survival.
Scientists identify key molecular regulator of cardiac hypertrophy
Scientists have identified a key molecular regulator of cardiac hypertrophy (enlargement of the heart) that may provide a therapeutic target for a major risk factor of heart failure and early death.
Genetically reprogrammed HSV given systemically shrinks distant sarcomas
Scientists have used a genetically reprogrammed herpes virus and an anti-vascular drug to shrink spreading distant sarcomas designed to model metastatic disease in mice - still an elusive goal when treating ...
Molecular signatures may aid fight against pediatric liver disease
Researchers have identified a set of "molecular signatures" for biliary atresia - the most common diagnosis leading to liver transplant in children - that can help identify the progression of disease at diagnosis and predict ...
High fructose, trans fats lead to significant liver disease, says study
Scientists at Cincinnati Children's Hospital Medical Center have discovered that a diet with high levels of fructose - levels equivalent to that in high fructose corn syrup - and of trans fats not only increases obesity, ...
Racial disparities evident in taking sexual histories in emergency departments
Emergency department physicians are more likely to document sexual histories of black adolescent girls with symptoms potentially related to sexually transmitted infections (STI) than white teen girls with the same symptoms, ...