Baylor College of Medicine (BCM) was established in 1900 in Houston, Texas. BCM is a top rated university hospital for patient care and biomedical research. BCM is rated 13th overall for all medical schools in the United States by U.S. News and World Report 2009. BCM is rated 2nd for federal funding for research among all medical schools in the USA. Baylor is located in the Texas Medical Center and has affiliations with 8 teaching hospitals in the Houston area. BCM scientist/MD Zoghbi was awarded the Vilcek Award for 2009 for biomedical research. BCM is a private medical school.
Genes define the interaction of social amoeba and bacteria
Amoeba eat bacteria and other human pathogens, engulfing and destroying them – or being destroyed by them, but how these single-cell organisms distinguish and respond successfully to different bacterial ...
Gene network illuminates stress, mutation and adaptation responses
For much of her professional life, Dr. Susan Rosenberg has studied the puzzling response of bacteria to stress and the mutations that result. In the current issue of the journal Science, she puts together the pieces of tha ...
Jigsaw a critical piece of the Notch puzzle
The Notch signaling pathway helps determine cell fate determination, differentiation and proliferative ability of numerous cells. How it accomplishes these tasks has been a puzzle, but researchers led by those at Baylor College ...
Architecture of rod sensory cilium disrupted by mutation
Using a new technique called cryo-electron tomography, two research teams at Baylor College of Medicine have created a three-dimensional map that gives a better understanding of how the architecture of the rod sensory cilium ...
Feedback loop maintains basal cell population
Notch – the protein that can help determine cell fate – maintains a stable population of basal cells in the prostate through a positive feedback loop system with another key protein – TGF beta (transforming growth factor ...
Battles between steroid receptors to regulate fat accumulation
The androgen receptor in human cells inhibits fat accumulation, but its activity can be sabotaged by glucocorticoids, steroids that regulate fat deposition and are known drivers of obesity and insulin resistance, said researchers ...
Semi-automated 'pathwalking' to build a protein model
A new semi-automated tool called pathwalking makes it possible to generate a "first draft" model of a protein fold taken from near-atomic resolution images of between three and six angstroms (Å), said researchers at ...
Fruit flies drawn to the sweet smell of youth
Aging takes its toll on sex appeal and now an international team of researchers led by Baylor College of Medicine and the University of Michigan find that in fruit flies, at least, it even diminishes the come-hither ...
Membrane fusion a mystery no more
The many factors that contribute to how cells communicate and function at the most basic level are still not fully understood, but researchers at Baylor College of Medicine have uncovered a mechanism that helps explain how ...
Understanding the beginnings of embryonic stem cells helps predict the future
Ordinarily, embryonic stem cells exist only a day or two as they begin the formation of the embryo itself. Then they are gone.
Self or non-self: Social amoeba rely on genetic 'lock and key' to identify kin
The ability to identify self and non-self enables cells in more sophisticated animals to ward off invading infections, but it is critical to even simpler organisms such as the social amoebae Dictyostelium discoideum.
Extensive protein interaction network controls gene regulation
The genes of a cell are like the 88 keys of a piano. To play chords and music, however, the keys must be activated in exact combinations by a pianist's hands. Those hands represent the coregulators of a cell that simultaneously ...
Microarray analysis can identify unsuspected incest
Researchers using DNA microarrays to diagnose developmental disabilities or congenital anomalies in children may unexpectedly identify that some have been conceived through incest. This raises social and legal issues that ...
Single cell studies identify coactivator role in fat cell maturation
All fat cells are not the same a fact that has implications in the understanding and treatment of type 2 diabetes and obesity, said researchers from Baylor College of Medicine in a report that appears in the current ...
'UnZIPPING' zinc protects hippocampal neurons
Zinc ions released at the junction between two neurons (called a synapse) are important signals, but when too much zinc accumulates, cells become dysfunctional or die.