Risk of Parkinson's disease increases with pesticide exposure and head trauma

May 30, 2007

[B]Environmental risk factors for Parkinson's disease and Parkinsonism: the Geoparkinson study[/B]
Exposure to pesticides and traumatic head injury may have a causative role in Parkinson's disease, according to a study published online ahead of print in the journal Occupational and Environmental Medicine.

And the risk of developing Parkinson's disease increases according to the level of exposure, the results showed.

The two risk factors are potentially modifiable, the authors say. Head trauma resulting from contact sports such as boxing can be avoided and further research could identify more specifically which pesticides are associated with this effect, so that these agents can be substituted.

People who had been exposed to low levels of pesticides were found to be 1.13 times as likely to have Parkinson's disease compared with those who had never been exposed. Those who had been exposed to high levels of pesticides were 1.41 times as likely to be affected.

Parkinson's disease occurred 1.35 times more frequently in people who had been knocked unconscious once compared with those who had never been knocked out, and arose 2.53 times more frequently in those who had been knocked out more frequently.

The European Commission funded study is one of the largest case-control studies to date of genetic, environmental and occupational risk factors for Parkinson's disease or other degenerative parkinsonian syndromes. It involved 959 prevalent cases of parkinsonism (767 with Parkinson's disease) and 1989 controls recruited in Scotland, Italy, Sweden, Romania and Malta.

Cases were defined using the UK Parkinson's Disease Society Brain Bank criteria. Patients with drug-induced or vascular parkinsonism or dementia were excluded.

Subjects completed a questionnaire regarding their lifetime occupational and recreational exposure to solvents, pesticides, iron, copper and manganese. Their lifetime exposure was then estimated blind to disease status and the results were adjusted, as appropriate, for age, sex, country of residence, tobacco use, ever having been knocked unconscious and family history of Parkinson's disease.


Source: BMJ Specialty Journals

Explore further: Philippines boosts MERS monitoring after UAE nurse scare

add to favorites email to friend print save as pdf

Related Stories

Japan lab says stem cell research falsified (Update 3)

Apr 01, 2014

The finding that a lead researcher falsified data in a widely heralded stem-cell research paper is a setback for Japan's efforts to promote its advanced research, but also a symptom of the pressure for breakthroughs ...

Recommended for you

US orders farms to report pig virus infections

19 hours ago

The U.S. government is starting a new program to help monitor and possibly control the spread of a virus that has killed millions of pigs since showing up in the country last year.

Foreigner dies of MERS in Saudi

20 hours ago

A foreigner has died after she contracted MERS in the Saudi capital, the health ministry said on announced Friday, bringing the nationwide death toll to 73.

Vietnam battles fatal measles outbreak

23 hours ago

Vietnam is scrambling to contain a deadly outbreak of measles that has killed more than 100 people, mostly young children, and infected thousands more this year, the government said Friday.

New clues on tissue scarring in scleroderma

Apr 18, 2014

A discovery by Northwestern Medicine scientists could lead to potential new treatments for breaking the cycle of tissue scarring in people with scleroderma.

User comments : 0

More news stories

Health care site flagged in Heartbleed review

People with accounts on the enrollment website for President Barack Obama's signature health care law are being told to change their passwords following an administration-wide review of the government's vulnerability to the ...

Airbnb rental site raises $450 mn

Online lodging listings website Airbnb inked a $450 million funding deal with investors led by TPG, a source close to the matter said Friday.