New blood pressure drug found lacking

May 10, 2007

A U.S. study has determined the first of a new class of drugs designed to treat hypertension has limited effectiveness.

There are currently seven classes of drugs used to reduce blood pressure. Aliskiren (Tekturna and Rasilez) is the first of a new class of orally active anti-hypertensive drugs that works by inhibiting the enzyme rennin that can raise blood pressure.

But a review of six large-scale clinical trials of aliskiren by Jean Sealey and Dr. John Laragh of the Weill Cornell Medical College found, because of reactive renin secretion, the drug has not been any more effective than those already widely available to control hypertension.

Laragh and Sealey found in analyzing clinical trials involving more than 5,000 hypertensive patients, aliskiren was no more effective as an anti-hypertensive agent than converting enzyme inhibitors, angiotensin receptor blockers or diuretics.

The research is detailed in the May issue of the American Journal of Hypertension.

Copyright 2007 by United Press International

Explore further: Two studies of cannabidiol oil as a treatment for severe, intractable seizures

add to favorites email to friend print save as pdf

Related Stories

Far from home: Wayward cluster is both tiny and distant

45 minutes ago

Like the lost little puppy that wanders too far from home, astronomers have found an unusually small and distant group of stars that seems oddly out of place. The cluster, made of only a handful of stars, ...

Recommended for you

FDA warning: men's testosterone drugs overused (Update)

Mar 03, 2015

The Food and Drug Administration is warning doctors against over-prescribing testosterone-boosting drugs for men, saying the popular treatments have not been established as safe or effective for common age-related ...

Early benefit assessment increases transparency for study data

Mar 03, 2015

Four years have passed since the introduction of the German Act on the Reform of the Market for Medicinal Products (AMNOG). AMNOG was primarily aimed at containing the increasing drug expenditure of the statutory health insurance ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.