New blood pressure drug found lacking

May 10, 2007

A U.S. study has determined the first of a new class of drugs designed to treat hypertension has limited effectiveness.

There are currently seven classes of drugs used to reduce blood pressure. Aliskiren (Tekturna and Rasilez) is the first of a new class of orally active anti-hypertensive drugs that works by inhibiting the enzyme rennin that can raise blood pressure.

But a review of six large-scale clinical trials of aliskiren by Jean Sealey and Dr. John Laragh of the Weill Cornell Medical College found, because of reactive renin secretion, the drug has not been any more effective than those already widely available to control hypertension.

Laragh and Sealey found in analyzing clinical trials involving more than 5,000 hypertensive patients, aliskiren was no more effective as an anti-hypertensive agent than converting enzyme inhibitors, angiotensin receptor blockers or diuretics.

The research is detailed in the May issue of the American Journal of Hypertension.

Copyright 2007 by United Press International

Explore further: Experts want restrictions on testosterone drug use (Update)

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Experts want restrictions on testosterone drug use (Update)

12 hours ago

Federal health experts said Wednesday there is little evidence that testosterone-boosting drugs are effective for treating common signs of aging in men and that their use should be narrowed to exclude millions of Americans ...

Big cities take aim at prescription painkillers

Sep 16, 2014

Some of the nation's largest cities are ratcheting up their criticism of prescription painkillers, blaming the industry for a wave of addiction and overdoses that have ravaged their communities and busted local budgets.

World Health Organization policy improves use of medicines

Sep 16, 2014

In this issue of PLOS Medicine, Kathleen Holloway from WHO and David Henry (University of Toronto, Canada) evaluated data on reported adherence to WHO essential medicines practices and measures of quality use of medicines from 5 ...

User comments : 0