Tissue engineered scaffolding allows reproduction of cartilage tissue

May 09, 2007

A new study examines the use of tissue-engineered scaffolding made of cartilage cells, which have a limited ability to heal naturally, to replace defective cartilage tissue. Cartilage cells are extracted and seeded to the scaffold which is implanted into the body, where new cartilage tissue is grown along the structure. The study appears in the journal Artificial Organs.

The procedure was extremely successful in tested mice as the study found these scaffolds to be a far more effective means of regenerating cartilage than traditional therapy. The shrinkage of cartilage that occurs frequently in other tissue engineering methods, and often renders the replacement tissue wrongly-sized for implantation, did not occur in the study. The scaffolding allowed the newly grown cartilage to maintain its volume during cultivation and post-procedure.

"The cell-derived scaffold could provide a favorable environment for cartilage cells to maintain their characteristics while synthesizing cartilage in the scaffold structure in vivo," notes study author Dr. Byoung-Hyun Min. "Cell-derived scaffolding may hold great promise for the future. A variety of applications are possible for the engineering of cartilage tissue as the shape and porosity can be altered to suit the type of tissue required."

Source: Blackwell Publishing Ltd.

Explore further: Platelets modulate clotting behavior by 'feeling' their surroundings

add to favorites email to friend print save as pdf

Related Stories

Finding the sweet spot for cartilage formation

Aug 13, 2014

Joint injuries often fail to mend properly when not given assistance. In particular, cartilage exhibits a poor capacity for self-repair. It is possible to stimulate regeneration by implanting synthetic scaffolds ...

New method to grow synthetic collagen unveiled

Sep 08, 2011

In a significant advance for cosmetic and reconstructive medicine, scientists at Rice University have unveiled a new method for making synthetic collagen. The new material, which forms from a liquid in as ...

New tissue scaffold regrows cartilage and bone

May 11, 2009

(PhysOrg.com) -- MIT engineers and colleagues have built a new tissue scaffold that can stimulate bone and cartilage growth when transplanted into the knees and other joints.

Recommended for you

A better way to track emerging cell therapies using MRIs

Sep 19, 2014

Cellular therapeutics – using intact cells to treat and cure disease – is a hugely promising new approach in medicine but it is hindered by the inability of doctors and scientists to effectively track the movements, destination ...

User comments : 0