Multiple myeloma clinical trial closes early

Apr 05, 2007

Mayo Clinic Cancer Center announced today that a multiple myeloma clinical trial has shown a significant improvement in survival with lenalidomide plus low-dose dexamethasone therapy compared to lenalidomide plus high-dose dexamethasone.

The study led by the Eastern Cooperative Oncology Group (ECOG) and supported by the National Cancer Institute compared combination treatment of oral medications lenalidomide and either high- or low-dose dexamethasone in 445 patients with newly-diagnosed myeloma. Lenalidomide plus high-dose dexamethasone had a one-year survival rate of 86 percent. The comparative therapy using low-dose dexamethasone showed a significantly higher 96.5 percent overall survival rate at one year, with much less toxicity.

"In my opinion, this is the best one-year survival data that I’ve seen in a large phase 3 study in myeloma," says Vincent Rajkumar, M.D., Mayo Clinic hematologist and primary investigator of the ECOG study. "This is a major advance in the treatment of this cancer."

All patients on the high-dose dexamethasone arm of the clinical trial will be moved to the low-dose arm. A successor study using lenalidomide plus high-dose dexamethasone was closed early as a result of these findings.

Source: Mayo Clinic

Explore further: Many women receive unnecessary Pap tests

add to favorites email to friend print save as pdf

Related Stories

And now the Acropolis is crumbling...

29 minutes ago

Just when Greece thought it had come through the worst of the crisis it was hit by a new blow Wednesday—the Acropolis is crumbling.

Alaska refuge proposes killing invasive caribou

1 hour ago

Federal wildlife officials are considering deadly measures to keep an Alaska big game animal introduced more than 50 years ago to a remote island in the Aleutians from expanding its range.

Recommended for you

Obesity tied to higher cancer risk for CRC survivors

32 minutes ago

(HealthDay)—Colorectal cancer (CRC) patients who are overweight or obese when diagnosed appear to face a slightly higher risk for developing a second weight-related cancer, according to research published ...

Many women receive unnecessary Pap tests

7 hours ago

As many as half to two-thirds of women who have undergone hysterectomies or are older than 65 years in the United States report receiving  Pap tests for cervical cancer. This prevalence is surprising in ...

User comments : 0