Study into ancestry of Thomas Jefferson shows rare class of DNA

Mar 28, 2007

DNA testing carried out by University of Leicester geneticists and funded by The Wellcome Trust has thrown new light on the ancestry of one of the USA’s most revered figures, the third President, Thomas Jefferson.

Almost 10 years ago, the University of Leicester team, led by Professor Mark Jobling, together with international collaborators, showed that Thomas Jefferson had fathered at least one of the sons of Sally Hemings, a slave of Jefferson’s.

The work was done using the Y chromosome, a male-specific part of our DNA that passes down from father to son. Jefferson carried a very unusual Y chromosome type, which helped to strengthen the evidence in the historical paternity case.

Now, new techniques have been brought to bear on Jefferson’s Y chromosome, in a study reported in the American Journal of Physical Anthropology. The presidential chromosome turns out to belong to a rare class called ‘K2’, which is found at its highest frequency in the Middle East and Eastern Africa, including Oman, Somalia and Iraq. Its closest match was in a man from Egypt. Could this mean that the President had recent ancestry in the Middle East? A careful survey revealed a few K2 chromosomes in France, Spain and England. Together, the K2s form a diverse group that may, in fact, have been in western Europe for many thousands of years.

Further evidence for Jefferson’s British origins come from the finding that two out of 85 randomly recruited men named Jefferson share exactly the same Y chromosome as the President. Prof Jobling said: ‘The two men have ancestry in Yorkshire and the West Midlands, and knew of no historical connection to the USA. They were amazed and fascinated by the link, which connects them into Thomas Jefferson’s family tree, probably about 11 generations ago.’

The ultimate origins of K2 chromosomes remain a mystery, however, and need further investigation: while they may have been present in Europe since the Stone Age, another possibility is that K2s came to Europe with the Phoenicians, an ancient maritime trading culture that spread out across the Mediterranean from their home in what is now Lebanon. The US media has taken up a different theory, leading to the New York Times headline, ‘Jefferson – the first Jewish president?’: European K2 chromosomes may originate in Sephardic (Spanish) Jewish populations, who have their ultimate origins in the Middle East.

Prof Jobling said: ‘When we look closely at large collections of British Y chromosomes we find surprises, like this rare K2 lineage, and the African chromosome that we recently found in a Yorkshireman. These exotic chromosomes remind us of the complexity of British history and prehistory.’

Source: University of Leicester

Explore further: Organovo has 3D-printed liver tissue for drug testing

add to favorites email to friend print save as pdf

Related Stories

New studies explain how cancer cells 'eat us alive'

Sep 01, 2010

Four key studies now propose a new theory about how cancer cells grow and survive, allowing researchers to design better diagnostics and therapies to target high-risk cancer patients. These studies were conducted by a large ...

National study to identify genetic variants in schizophrenia

Apr 27, 2009

The Medical College of Georgia is part of a large national study examining the genes of 10,000 patients with schizophrenia and 10,000 healthy individuals in an effort to pinpoint variations that can improve disease diagnosis ...

DNA could reveal your surname

Oct 08, 2008

(PhysOrg.com) -- Scientists at the world-leading Department of Genetics at the University of Leicester – where the revolutionary technique of genetic fingerprinting was invented by Professor Sir Alec Jeffreys- are developing ...

Recommended for you

Organovo has 3D-printed liver tissue for drug testing

9 hours ago

(Medical Xpress)—The commercial release of 3D printed liver tissue was announced earlier this week. Organovo is the company behind the release. The product is intended for use for preclinical drug discovery ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.