Fruit fly gene research may shed light on human disease processes

Mar 27, 2007

Those small fruit flies buzzing around your bananas are more than pests—they may be allies in a fruitful search for clues to human diseases caused when genes malfunction.

"One common misconception is that individual humans may carry 'disease-causing' genes, such as a gene for cancer," explains James Erickson, a biology professor at Texas A&M University. "All humans have the same genes, but individual genes have different forms, called alleles, some of which may predispose an individual to a disease."

"Studying the common fruit fly – Drosophilia melanogaster -- lets us conduct more sophisticated experiments than can be undertaken in humans. These simple organisms can be grown cheaply in test tubes, fed on yeast, corn meal and molasses, yet their embryos, which can be seen with the naked eye, undergo many of the same developmental processes as larger creatures. Thus, they can serve as models, allowing us to observe details we can't see in more complex animals."

To understand cellular differentiation, Erickson and his graduate students have been researching how fly embryos become male or female, a process that occurs over a 30-minute period early in their development and which is similar to the differentiation process for different types of cells, mirroring, for example, the way a liver cell becomes different from a blood cell.

Erickson cautions that there is no direct connection between sexual development in flies and that of humans, but the logic driving their cellular and molecular processes is the same. A paper by Erickson and postdoctoral student Frank Avila detailing their work on such processes has been published in this month's issue of Current Biology, a leading biology journal.

Human females have two X chromosomes in every cell, while human males have an X and a Y chromosome. "Just as in mammals, flies have two 'sex' chromosomes, a X and a Y" he explains. "However, in the fly, unlike in humans, the Y chromosome does not influence sex. Instead, two X chromosomes signal the fly to be female, and one X chromosome means it will be male."

A chromosome is a single DNA molecule that may contain different units of inheritance called genes, along with proteins that help to activate these genes under certain conditions.

Even though it is the presence or absence of the human Y chromosome that directs sex development, human females still need to determine how many X chromosomes they have in each cell. They do this to ensure that similar amounts of the proteins encoded on the X chromosomes are produced in each sex. Failure to properly count X chromosomes is lethal to embryos of mammals and flies. That's why biologists want to understand the process of "chromosome counting."

Early in his career, Erickson was part of the research team that identified the genes involved in counting Drosophilia sex chromosomes. Now, he and Avila have made another breakthrough, identifying a signaling pathway outside the cell that helps trigger a cascade of proteins to ensure embryos remain either male or female once their sex has been determined, as well as help in the chromosome-counting process and in regulating other crucial cell activities.

"This signaling process is not unique to embryonic sex differentiation, but occurs in hundreds of genes throughout the body, in flies and in higher animals, too," Avila says. "Our work sheds light on signal transmission in humans."

Erickson points out that flies have evolved along with humans and that the two species are "close."

Although he is quick to point out that the group's research has no short-term practical application, he believes down the road it has important implications for human health.

"Scientists have been trying to understand how the sex of mosquitoes is determined, with an eye to eradicating those which carry diseases," he says. "Our research on fruit flies may help in this quest."

"Additionally, many human diseases are linked to genes carried on the X chromosome. That's why women do not suffer in the same numbers as men from such ailments as color blindness or hemophilia, since their double dose of X genetic material helps compensate for 'defective' genes on one of their chromosomes. Men, with just one X chromosome, have less protection. Understanding the role of the X chromosome and the mechanism of chromosome counting in fruit flies may help shed light on these same features in humans."

Besides potentially shedding light on human genetic maladies, Erickson and Avila say their work is just plain interesting.

"After all," says Erickson, "fruit flies share the same life cycle as butterflies – they're just not as pretty."

Source: Texas A&M University

Explore further: DNA study could shed light on how genetic faults trigger disease

Related Stories

Fruit flies crucial to basic research

Mar 30, 2015

The world around us is full of amazing creatures. My favorite is an animal the size of a pinhead, that can fly and land on the ceiling, that stages an elaborate (if not beautiful) courtship ritual, that can ...

Letting go of the (genetic) apron strings

Mar 20, 2015

A new study from Princeton University sheds light on the handing over of genetic control from mother to offspring early in development. Learning how organisms manage this transition could help researchers ...

A first of its kind tool to study the histone code

Feb 10, 2015

University of North Carolina scientists have created a new research tool, based on the fruit fly, to help crack the histone code. This research tool can be used to better understand the function of histone proteins, which ...

Recommended for you

Systematic interaction network filtering in biobanks

22 hours ago

While seeking targets to attack Huntington's disease, an incurable inherited neurodegenerative disorder, neurobiologists of the research group led by Professor Erich Wanker of the Max Delbrück Center for ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.