Scientists demonstrate the process of mammalian egg maturation

Feb 05, 2007

The Rong Li lab team has answered an important question about how mammalian eggs undergo maturation through an intricate process of asymmetric cell division. The team discovered a novel pathway by which chromatin exerts command on the cell membrane to produce a specialized machinery used for cell division.

The paper, "Chromatin-derived signals control asymmetric meiotic cell division in mouse oocytes," will be published in the Feb. 6 issue of Developmental Cell. It examines how mammalian eggs undergo a maturation process to achieve genomic reduction, while maintaining as many useful building blocks as possible for later embryonic development.

"This study provides important clues to the molecular signals used by the chromatin to communicate with the cell membrane in order for the cell division machine to be assembled at the right place," said Rong Li, Ph.D., Investigator. "It also appears that there are significant differences between this cell division process and the studied process occuring in somatic cells. Therefore, the egg system provides an unique paradigm for understanding the basic strategies that mammalian cells use to undergo specialized cell divisions."

"The process of egg maturation is critical for reproduction," said Robb Krumlauf, Ph.D., Scientific Director. "Any mistake in this process can lead to infertility or developmental abnormalities. The Li lab's findings open the door to a better understanding of the molecular basis of cell division during egg maturation in mammalian organisms."

Source: Stowers Institute for Medical Research

Explore further: YEATS protein potential therapeutic target for cancer

add to favorites email to friend print save as pdf

Related Stories

Beastly sunspot amazes, heightens eclipse excitement

30 minutes ago

That's one big, black blemish on the Sun today! Rarely have we been witness to such an enormous sunspot. Lifting the #14 welder's glass to my eyes this morning I about jumped back and bumped into the garage.

Scientists develop compact medical imaging device

1 hour ago

Scientists at the MIRA research institute, in collaboration with various companies, have developed a prototype of a handy device that combines echoscopy (ultrasound) with photoacoustics. Combining these two ...

Software models ocean currents for oil and gas search

1 hour ago

A study involving the use of streamline visualisation has found the technology can help guide electromagnetic transmitter and receiver placements, thereby aiding the search for oil and gas on the seafloor.

Intelligent materials that work in space

1 hour ago

ARQUIMEA, a company that began in the Business Incubator in the Science Park of the Universidad Carlos III de Madrid, will be testing technology it has developed in the International Space Station. The technology ...

Recommended for you

YEATS protein potential therapeutic target for cancer

just added

Federal Express and UPS are no match for the human body when it comes to distribution. There exists in cancer biology an impressive packaging and delivery system that influences whether your body will develop cancer or not.

Precise and programmable biological circuits

1 hour ago

A team led by ETH professor Yaakov Benenson has developed several new components for biological circuits. These components are key building blocks for constructing precisely functioning and programmable bio-computers.

User comments : 0