Yale scientists map cell signaling network

Nov 30, 2005

Yale University scientists have mapped, for the first time, the proteins and kinase signaling network that control how cells of higher organisms operate.

The researchers said their study is a breakthrough in understanding how proteins operate in different cell types under the control of master regulator molecules called protein kinases.

Although protein kinases are already important targets of cancer drugs, until recently it has been difficult to identify the proteins regulated by the kinases.

Led by Michael Snyder, a professor of molecular, cellular and developmental biology, the researchers focused on the expression and relationship between proteins of the yeast cell "proteome," or the proteins that are active in a cell.

Protein kinases act as regulator switches and modify their target proteins by adding a phosphate group to them. The process, called "phosphorylation," results in altered activity of the phosphorylated protein. It is estimated 30 percent of all proteins are regulated by that process.

The research is explained in this week's issue of the journal Nature.

Copyright 2005 by United Press International

Explore further: Ancient clay seals may shed light on biblical era

add to favorites email to friend print save as pdf

Related Stories

The origin of the language of life

Dec 19, 2014

The genetic code is the universal language of life. It describes how information is encoded in the genetic material and is the same for all organisms from simple bacteria to animals to humans. However, the ...

Recommended for you

Ancient clay seals may shed light on biblical era

7 hours ago

Impressions from ancient clay seals found at a small site in Israel east of Gaza are signs of government in an area thought to be entirely rural during the 10th century B.C., says Mississippi State University archaeologist ...

Digging up the 'Spanish Vikings'

Dec 19, 2014

The fearsome reputation of the Vikings has made them the subject of countless exhibitions, books and films - however, surprisingly little is known about their more southerly exploits in Spain.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.