Scientists study Helicobacter pylori

Dec 11, 2006

French scientists have outlined the biological role of a potassium channel in a pathogen that colonizes the stomach.

Kerstin Stingl and colleagues at the Pasteur Institute in Paris studied Helicobacter pylori, an unusual bacterium that lacks all known potassium uptake systems, but instead has one putative potassium channel, HpKchA.

They showed, for the first time, that channel is essential for potassium uptake into H. pylori at low external concentrations, and for colonization of the mucus lining of the stomach. The role of HpKchA as a bulk potassium uptake system represents an adaptation to the hostile, but competitor-free, gastric environment.

The findings follow recent reports that H. pylori is involved in several gastric pathologies, including chronic gastritis, gastric and duodenal ulcers and gastric cancer. The scientists say their study's results might have implications for drug development to treat H. pylori-associated gastric diseases.

The research appears online in The EMBO Journal.

Copyright 2006 by United Press International

Explore further: Australian treatment could save wounded soldiers

add to favorites email to friend print save as pdf

Related Stories

Form Devices team designs Point as a house sitter

3 hours ago

A Scandinavian team "with an international outlook" and good eye for electronics, software and design aims to reach success with what they characterize as "a softer take" on home security. Their device is ...

Man pleads guilty in New York cybercrime case

6 hours ago

A California man has pleaded guilty in New York City for his role marketing malware that federal authorities say infected more than a half-million computers worldwide.

NASA issues 'remastered' view of Jupiter's moon Europa

14 hours ago

(Phys.org) —Scientists have produced a new version of what is perhaps NASA's best view of Jupiter's ice-covered moon, Europa. The mosaic of color images was obtained in the late 1990s by NASA's Galileo ...

Dish restores Turner channels to lineup

15 hours ago

Turner Broadcasting channels such as Cartoon Network and CNN are back on the Dish network after being dropped from the satellite TV provider's lineup during contract talks.

Recommended for you

A hybrid vehicle that delivers DNA

21 hours ago

A new hybrid vehicle is under development. Its performance isn't measured by the distance it travels, but rather the delivery of its cargo: vaccines that contain genetically engineered DNA to fight HIV, cancer, ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.