Immune responses spread from one protein to another in type 1 diabetes

Dec 02, 2006

Type 1 diabetes (T1D) occurs when the immune system inappropriately attacks cells in the pancreas. Although many of the proteins attacked during T1D have been identified, it has not been determined whether immune responses to the individual proteins develop independently or whether a response to one protein then spreads to others. Now, a new study shows that in mice the immune system first attacks a single protein and then expands its attack to other proteins.

Using mice that develop a disease very similar to T1D (NOD mice), Thomas Kay and colleagues showed that NOD mice that were unable to mount an immune response to proinsulin also had no immune cells that recognized a second protein IGRP and did not develop diabetes.

By contrast, NOD mice that were unable to mount an immune response to IGRP had immune cells that recognize proinsulin and developed diabetes. This study demonstrates that diabetes in NOD mice is triggered by an immune response to a single protein that then spreads to other proteins. This study therefore has important implications for the development of therapeutics designed to make individuals with T1D no longer mount an immune response to a particular protein.

In an accompanying commentary, Lucienne Chatenoud and Sylvaine You from the HĂ´pital Necker-Enfants Malades, France, discuss how it is important to determine the molecular and cellular events that underlie this spreading of the immune response so that the information can be translated to therapeutics for T1D and perhaps other autoimmune diseases.

Source: Journal of Clinical Investigation

Explore further: Stroke damage mechanism identified

add to favorites email to friend print save as pdf

Related Stories

Senators get no clear answers on air bag safety

7 hours ago

There were apologies and long-winded explanations, but after nearly four hours of testimony about exploding Takata air bags, senators never got a clear answer to the question most people have: whether or ...

Nicaragua: Studies say canal impact to be minimal

7 hours ago

Officials said Thursday that studies have determined a $40 billion inter-oceanic canal across Nicaragua will have minimal impact on the environment and society, and construction is to begin next month.

Former Brown dean whose group won Nobel Prize dies

8 hours ago

David Greer, a doctor who co-founded a group that won the 1985 Nobel Peace Prize for working to prevent nuclear war and who helped transform the medical school at Brown University, has died. He was 89.

Recommended for you

Stroke damage mechanism identified

2 hours ago

Researchers have discovered a mechanism linked to the brain damage often suffered by stroke victims—and are now searching for drugs to block it.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.