Smoking changes brain chemistry

Nov 28, 2006

Chronic smoking affects nerve cells and alters the chemical makeup of the brain, according to research presented today at the annual meeting of the Radiological Society of North America.

"This is the first imaging study to focus on the relationship between brain metabolites and nicotine dependence," said Okan Gür, M.D., from the Department of Radiology at the University of Bonn in Germany.

Dr. Gür and colleagues used proton magnetic resonance spectroscopy (MRS) to study 21 men and 22 women, age 21 to 59, in a smoking cessation program two weeks after quitting and again six months later. Patients were encouraged to use nicotine patches during the initial six weeks of smoking cessation; however, only 36 of the patients complied.

Proton MRS is able to measure brain metabolism at the cellular level and can provide detailed chemical data about the brain's metabolites, which are involved in many physical and chemical processes within the body.

The researchers compared the data collected from the smokers to proton MRS data collected from 35 age- and gender-matched healthy controls.

The results showed that the nicotine-dependent patients had significantly decreased concentrations of the amino acid N-acetylaspartate (NAA) in the anterior cingulate cortex (ACC), the part of the brain that processes pleasure and pain. The decreased NAA levels were evident regardless of whether or not the patient used a nicotine patch and correlated directly with the patient's smoking history: the greater the number of pack years (one pack per day for one year equals one pack year), the lower the NAA level.

"The ACC is involved in mediating conditioned reinforcement, craving and relapsing behavior in addiction," said study co-author Christian G. Schütz, M.D., M.P.H., from the Department of Psychiatry at the University of Bonn. "Lower NAA levels have been implicated as indicators of neuronal or axonal dysfunction."

Reduced NAA levels have been reported for a number of psychiatric and mood disorders, including schizophrenia, dementia and bipolar disorder, as well as in cases of substance abuse, particularly alcohol dependence.

Choline concentrations in the ACC were slightly lower in the smokers compared with the nonsmokers, and lower still in the female smokers compared with the male smokers.

Choline is significantly involved in cell membrane metabolism, which is essential for cardiac and brain function. Reduced choline levels can be a precursor to the breakdown of cell membranes.

Concentration of total creatine (tCr) levels in the frontal lobes was typically higher in the smokers who did not use patches compared to those who did. The metabolite tCr plays an important role in supplying energy to the muscle cells. Higher tCr levels have been associated with stimulant use. Furthermore, the researchers found that high tCr levels predicted a higher likelihood of relapse.

Upon follow-up after six months, the researchers found that most metabolite concentrations, including that of NAA, had normalized in the 25 ex-smokers who did not relapse.

"These findings further emphasize the importance of quitting smoking," Dr. Gür said. "The degree of reduction of NAA in the ACC depends on the amount of tobacco consumed over time, but it appears to normalize after smoking cessation."

Source: Radiological Society of North America

Explore further: Uruguay begins registering marijuana growers

add to favorites email to friend print save as pdf

Related Stories

Oregon sues Oracle over failed health care website

4 hours ago

Oregon Attorney General Ellen Rosenblum says she's filed a lawsuit against Oracle Corp. and several of its executives over the technology company's role in the state's troubled health insurance exchange.

Google buys product design firm Gecko

4 hours ago

Google on Friday confirmed that it bought Gecko Design to bolster its lab devoted to technology-advancing projects such as self-driving cars and Internet-linked Glass eyewear.

Lawsuits challenge US drone, model aircraft rules

4 hours ago

Model aircraft hobbyists, research universities and commercial drone interests filed lawsuits Friday challenging a government directive that they say imposes tough new limits on the use of model aircraft ...

Recommended for you

Uruguay begins registering marijuana growers

4 hours ago

Just a handful of people had registered by midday Wednesday to be private growers of marijuana in Uruguay, the first country to fully legalize the production, sale and distribution of the drug.

Tracking spending among the commercially insured

14 hours ago

Recent growth in health care spending for commercially insured individuals is due primarily to increases in prices for medical services, rather than increased use, according to a new study led by researchers at The Dartmouth ...

Taking aim at added sugars to improve Americans' health

18 hours ago

Now that health advocates' campaigns against trans-fats have largely succeeded in sidelining the use of the additive, they're taking aim at sugar for its potential contributions to Americans' health conditions. But scientists ...

User comments : 0