Brain tumor vaccine has promising results

Nov 22, 2006

U.S. cancer researchers say a vaccine for treating a recurrent brain cancer known as glioma has shown promising results in preliminary clinical trials.

Findings from the first group of six patients in the study -- being conducted at the University of California-San Francisco's Brain Tumor Research Center -- involved vitespen (trademarked as Oncophage), a vaccine made from the patient's own tumor.

The trial's preliminary results indicate the vaccine was associated with tumor-specific immune response in patients with recurrent, high-grade glioma.

Glioma is a type of primary tumor that arises from the glial cells -- the connective tissue cells that surround and support nerve cells. The most common site of involvement of a glioma is the brain. Malignant glioma is currently a fatal disease.

"This is the first documentation of a glioma-specific immune response after vaccination with vitespen," said Dr. Andrew Parsa, assistant professor in the University of California-San Francisco Department of Neurological Surgery and principal investigator of the trial. Based on the preliminary findings, a larger phase 2 study is planned for 2007.

The trial results were presented last week in Orlando, Fla., during a meeting sponsored by the Society of Neuro-Oncology.

Copyright 2006 by United Press International

Explore further: Pyridoxine-doxylamine drug safety data lacking

add to favorites email to friend print save as pdf

Related Stories

Climate conditions help forecast meningitis outbreaks

Mar 18, 2014

Determining the role of climate in the spread of certain diseases can assist health officials in "forecasting" epidemics. New research on meningitis incidence in sub-Saharan Africa pinpoints wind and dust ...

Brain tumor vaccine trial shows promising results

Apr 16, 2007

A vaccine for treating a recurrent cancer of the central nervous system that occurs primarily in the brain has shown promise in preliminary data from a clinical trial at the University of California, San Francisco.

A tiny, time-released treatment

Oct 09, 2013

Omid Farokhzad's vision of medicine's future sounds a lot like science fiction. He sees medicine scaled down, with vanishingly small nanoparticles playing a big role, delivering drug doses measured in molecules ...

Study turns parasite invasion theory on its head

Dec 23, 2012

Current thinking on how the Toxoplasma gondii parasite invades its host is incorrect, according to a study published today in Nature Methods describing a new technique to knock out genes. The findings coul ...

Chimpanzees are spontaneously generous after all

Aug 08, 2011

Researchers at the Yerkes National Primate Research Center have shown chimpanzees have a significant bias for prosocial behavior. This, the study authors report, is in contrast to previous studies that positioned ...

Recommended for you

Pyridoxine-doxylamine drug safety data lacking

3 hours ago

(Medical Xpress)—The most commonly prescribed drug for pregnant women suffering from morning sickness in their first trimester does not prevent birth defects even though drug safety data says it does, according to research ...

FDA approves new type 2 diabetes drug

20 hours ago

(HealthDay)—Millions of Americans with type 2 diabetes have a new treatment option with the U.S. Food and Drug Administration's approval Tuesday of a once-weekly injectable drug, Tanzeum.

AAFP provides tips to address patients' vaccine concerns

Apr 14, 2014

(HealthDay)—Physicians remain the biggest influence on whether patients get vaccinated, and must be prepared to address patients' reservations, according to an article published in the March/April issue ...

User comments : 0

More news stories

HIV+ women respond well to HPV vaccine

HIV-positive women respond well to a vaccine against the human papillomavirus (HPV), even when their immune system is struggling, according to newly published results of an international clinical trial. The study's findings ...

Revealing camouflaged bacteria

A research team at the Biozentrum of the University of Basel has discovered an protein family that plays a central role in the fight against the bacterial pathogen Salmonella within the cells. The so cal ...