Progress made in HIV vaccine development

Nov 16, 2006

U.S. researchers report successfully testing two candidate vaccines that may eventually be used together to protect against HIV infection.

Dr. Barney Graham and colleagues from the National Institutes of Health Vaccine Research Center, the Fred Hutchinson Cancer Research Center in Seattle, and GenVec Inc. tested two possible HIV vaccines with the hope of producing an immune response in healthy, uninfected adults.

One candidate was a plasmid DNA-based vaccine expressing genes from three dominant HIV subtypes, and the second used recombinant adenovirus serotype 5 (rAd5) as a vector to deliver similar HIV strains.

Both vaccines were tested in healthy, uninfected adult volunteers. The DNA vaccine was found safe and well-tolerated. By the 12th week following immunization, 97.5 percent of vaccinees experienced positive CD4 T cell responses and 40 percent experienced positive CD8 T cell responses.

The recombinant vector vaccine was also well-tolerated but higher doses led to adverse events such as pain and fever. By the fourth week following immunization, 93.3 percent of vaccinees experienced positive CD4 T cell responses, and 60 percent experienced positive CD8 T cell responses.

The study is detailed in the Dec. 15 issue of The Journal of Infectious Diseases.

Copyright 2006 by United Press International

Explore further: Point-of-care CD4 testing is economically feasible for HIV care in resource-limited areas

add to favorites email to friend print save as pdf

Related Stories

Most detailed picture ever of key part of hepatitis C

Nov 28, 2013

Scientists at The Scripps Research Institute (TSRI) have determined the most detailed picture yet of a crucial part of the hepatitis C virus, which the virus uses to infect liver cells. The new data reveal ...

Recommended for you

The genetics of coping with HIV

20 hours ago

We respond to infections in two fundamental ways. One, which has been the subject of intensive research over the years, is "resistance," where the body attacks the invading pathogen and reduces its numbers. Another, which ...

Long acting HIV drugs to be developed

Sep 11, 2014

HIV drugs which only need to be taken once a month are to be developed at the University of Liverpool in a bid to overcome the problem of 'pill fatigue'.

Puerto Rico partners on US HIV vaccine project

Sep 10, 2014

Puerto Rico's governor says the island's largest public university is partnering with federal agencies to oversee a U.S.-funded project aimed at trying to develop a prophylactic vaccine for the HIV virus that causes AIDS.

User comments : 0