Phase II Study: Revlimid successful

Oct 12, 2006

U.S. scientists say a Phase II trial of Revlimid in patients with incurable blood cancer has produced positive results.

The researchers at the Moffitt Cancer Center and Research Institute in Tampa., Fla., say the study found more than 75 percent of patients reduced their need for transfusions and two-thirds were completely freed from the need for transfusions.

Most significantly, in 45 percent of patients, there was no detectable trace of the cancer. After two years of follow-up, patients continue to respond and do well on treatment, representing a breakthrough in treatment for myelodysplastic syndrome, or MDS.

"These new, landmark data demonstrate that Revlimid in some cases, eliminates all signs of the cancer's genetic cause -- an abnormality on the chromosome 5 -- can reduce or even eliminate the need for transfusions in many patients with MDS, and after two years these responses have continued to hold," said Dr. Alan List, professor of oncology and medicine, the lead author of the study.

MDS, a cancer in which the bone marrow fails to make enough functioning blood cells, kills up to 70,000 people annually.

The research appears in the Oct. 5 issue of the New England Journal of Medicine.

Copyright 2006 by United Press International

Explore further: Study reveals a cause of poorer outcomes for African-American patients with breast cancer

Related Stories

Cancer wins may be bigger than they seem

Jun 09, 2010

(AP) -- Doctors reported gains against nearly every form of cancer at a conference that ended this week. Yet when Will Thomas heard about an advance against prostate cancer, he wanted to know just one thing: "Is it a cure?"

Recommended for you

DNA blood test detects lung cancer mutations

Apr 17, 2015

Cancer DNA circulating in the bloodstream of lung cancer patients can provide doctors with vital mutation information that can help optimise treatment when tumour tissue is not available, an international group of researchers ...

Tumors prefer the easy way out

Apr 17, 2015

Tumor cells become lethal when they spread. Blocking this process can be a powerful way to stop cancer. Historically, scientists thought that tumor cells migrated by brute force, actively pushing through whatever ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.