Drug may be alternative to castration

Aug 23, 2006

U.S. medical scientists have found an oral drug is an acceptable alternative to chemical castration to treat prostate cancer.

"In patients with locally-advanced disease, a daily 150 mg dose of bicalutamide (Casodex) following initial radiotherapy has shown significant clinical benefits in terms of overall survival and progression-free survival, compared with radiotherapy alone," said study author Dr. William See, chairman and professor of urology at the Medical College of Wisconsin and chief of urologic surgery at Milwaukee's Froedtert Hospital.

The double-blind, randomized study followed 1,370 early prostate cancer patients who received radiotherapy with curative intent. After a median follow-up of 7.2 years, the researchers found those receiving the daily Casodex regimen reduced their risk of disease progression by 44 percent, and overall risk of death by 35 percent, compared with those receiving a placebo.

"Although many of the adverse effects of castration therapy are manageable, they can have a detrimental effect on quality of life," said See "Here we have evaluated the efficacy and tolerability of a non-castration-based therapy, and found the survival rates to be similar."

The study appears in the Journal of Cancer Research and Clinical Oncology.

Copyright 2006 by United Press International

Explore further: Neuroscientists identify new way several brain areas communicate

add to favorites email to friend print save as pdf

Related Stories

Deadly frog fungus dates back to 1880s, studies find

1 hour ago

A deadly fungus responsible for the extinction of more than 200 amphibian species worldwide has coexisted harmlessly with animals in Illinois and Korea for more than a century, a pair of studies have found.

Think twice about investing in own company

2 hours ago

Employees whose retirement plan is invested in stock of the company where they work do not pull out money as the firms approach financial distress, a recently released, but yet to be published paper, co-authored ...

Recommended for you

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.