Gene's cancer role is identified

Aug 08, 2006

U.S. medical researchers say they've discovered a new cancer-promoting role for a gene potentially linked with breast, liver and other kinds of cancer.

The scientists at Harvard Medical School and Massachusetts General Hospital say their discovery that the gene YAP can transform mammary epithelial cells opens the door to understanding how a novel cell growth controlling pathway first discovered in fruit flies might be important in human cancers.

"We screened the DNA from breast cancer cells for amplifications that are associated with tumor development," said senior author Dr. Daniel Naber, a professor of medicine and director of the MGH Cancer Center. "The identification of these new potential cancer-causing genes is critical to uncovering novel pathways that drive the conversion of a normal cell to a cancerous one.

The research was conducted jointly by Haber and Joan Brugge, a biology professor at HMS.

The findings appear in the online early edition of the Proceedings of the National Academy of Sciences and will appear in the Aug. 15 print edition.

Copyright 2006 by United Press International

Explore further: Report urges individualized, cholesterol-targeted approach to heart disease and stroke

add to favorites email to friend print save as pdf

Related Stories

Tracing water channels in cell surface receptors

19 hours ago

G protein-coupled receptors (GPCRs) are the largest class of cell surface receptors in our cells, involved in signal transmission across the cell membrane. One of the biggest questions is how a signal recognized at the extracellular ...

Cellular RNA can template DNA repair in yeast

Sep 03, 2014

The ability to accurately repair DNA damaged by spontaneous errors, oxidation or mutagens is crucial to the survival of cells. This repair is normally accomplished by using an identical or homologous intact ...

Recommended for you

Dirty water raising health risk in flooded Kashmir

50 minutes ago

The floodwaters are finally receding in much of Kashmir, but health experts worry a crisis could be looming with countless bloated livestock floating across the waterlogged region and hundreds of thousands ...

Obama to announce major Ebola effort

3 hours ago

US President Barack Obama will Tuesday seek to "turn the tide" in the Ebola epidemic by ordering 3,000 US military personnel to West Africa and launching a major health care training and hygiene program.

Researchers debunk myth about Parkinson's disease

3 hours ago

Using advanced computer models, neuroscience researchers at the University of Copenhagen have gained new knowledge about the complex processes that cause Parkinson's disease. The findings have recently been ...

User comments : 0