Gene's cancer role is identified

Aug 08, 2006

U.S. medical researchers say they've discovered a new cancer-promoting role for a gene potentially linked with breast, liver and other kinds of cancer.

The scientists at Harvard Medical School and Massachusetts General Hospital say their discovery that the gene YAP can transform mammary epithelial cells opens the door to understanding how a novel cell growth controlling pathway first discovered in fruit flies might be important in human cancers.

"We screened the DNA from breast cancer cells for amplifications that are associated with tumor development," said senior author Dr. Daniel Naber, a professor of medicine and director of the MGH Cancer Center. "The identification of these new potential cancer-causing genes is critical to uncovering novel pathways that drive the conversion of a normal cell to a cancerous one.

The research was conducted jointly by Haber and Joan Brugge, a biology professor at HMS.

The findings appear in the online early edition of the Proceedings of the National Academy of Sciences and will appear in the Aug. 15 print edition.

Copyright 2006 by United Press International

Explore further: Death rates from lung cancer will overtake those for breast cancer in 2015 among EU women

add to favorites email to friend print save as pdf

Related Stories

Team enlarges brain samples, making them easier to image

Jan 15, 2015

Beginning with the invention of the first microscope in the late 1500s, scientists have been trying to peer into preserved cells and tissues with ever-greater magnification. The latest generation of so-called ...

The epigenetic switchboard

Jan 12, 2015

Epigenetic signals help determine which genes are activated at which time in a given cell. A novel analytical method enables systematic characterization of the relevant epigenetic tags, and reveals that the ...

Recommended for you

Generic form of nexium approved

8 hours ago

(HealthDay)—The first generic version of the heartburn drug Nexium (esomeprazole) has been approved by the U.S. Food and Drug Administration.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.