Genes involved in wound healing identified

Jul 27, 2006

Scottish scientists say they have identified two of the genes essential for wound healing mediated by endogenous electrical currents.

The University of Aberdeen researchers have visualized wound healing guided by an electric field and identified the genes governing the process as PI(3)Kgamma and PTEN.

Previous research has shown damage to epithelial tissue such as skin results in strong, directional ion flow and generates an internal electrical field. Such fields are thought to guide moving cells by a process known as electrotaxis, in order to heal the wound. However, direct evidence of such electrically guided cell movement has been lacking until now.

A team of university researchers led by Min Zhao and Josef Penninger used time-lapse photography to visualize electrotaxis in animal cell and tissue cultures. They found wounds may close faster or be driven open, depending on the direction of externally applied electrical signals similar in strength to those occurring naturally.

The researchers also identified the genes that control electrotaxis as PI(3)Kgamma and PTEN, and propose electrical signals may be used in the future to direct cell growth during wound healing in cell and tissue engineering.

The study appears in the journal Nature.

Copyright 2006 by United Press International

Explore further: Age at autism diagnosis differs between boys, girls

Related Stories

Chinese team performs gene editing on human embryo

Apr 23, 2015

(Phys.org)—A team of researchers in China has announced that they have performed gene editing on human embryos. In their paper uploaded to the open access site Protein & Cell (after being rejected by Nat ...

A new wrinkle for cell culture

Apr 23, 2015

Using a technique that introduces tiny wrinkles into sheets of graphene, researchers from Brown University have developed new textured surfaces for culturing cells in the lab that better mimic the complex ...

Detailing heterochromatin formation at the onset of life

Apr 01, 2015

Antoine Peters and his group at the Friedrich Miescher Institute for Biomedical Research (FMI) have elucidated the mechanisms controlling the packaging of chromatin in the early embryo. They have identified ...

Recommended for you

Age at autism diagnosis differs between boys, girls

7 minutes ago

Girls are diagnosed with autism spectrum disorder (ASD) later than boys, possibly because females exhibit less severe symptoms, according to a study to be presented Tuesday, April 28 at the Pediatric Academic Societies (PAS) ...

Bill seeks to expand coverage for Hawaii fertility law

27 minutes ago

A proposal in Hawaii's Legislature would expand a state mandate on fertility treatments to include same sex couples and single women, updating a law that now only offers such benefits to women who are married to men.

Chikungunya kills 25 in Colombia

45 minutes ago

The virus chikungunya has killed 25 people in Colombia in less than a year, the National Health Institute said Monday.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.